{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:43:33Z","timestamp":1760708613542,"version":"3.37.3"},"reference-count":104,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["N N402 591840","NN402 591940"],"award-info":[{"award-number":["N N402 591840","NN402 591940"]}]},{"name":"Polish Ministry of Science and Higher Education","award":["N N402 591840","NN402 591940"],"award-info":[{"award-number":["N N402 591840","NN402 591940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. We investigated the association between genotypes and haplotypes of the c.-61G&gt;T (rs 1801320) and c.-98G&gt;C (rs 1801321) polymorphisms of the<jats:italic>RAD51<\/jats:italic>gene and the occurrence of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD) in dependence on some environmental factors.<jats:italic>Methods<\/jats:italic>. The polymorphisms were genotyped in peripheral blood lymphocytes of 100\u2009KC and 100\u2009FECD patients as well as 150 controls with PCR-RFLP.<jats:italic>Results<\/jats:italic>. The G\/T genotype of the c.-61G&gt;T polymorphism was associated with significantly increased frequency occurrence of KC (crude OR 2.99, 95% CI 1.75\u20135.13). On the other hand, the G\/G genotype of this polymorphism was positively correlated with a decreased occurrence of this disease (crude OR 0.52, 95% CI 0.31\u20130.88). We did not find any correlation between genotypes\/alleles of the c.-98G&gt;C polymorphism and the occurrence of KC. We also found that the G\/G genotype and G allele of the c.-98G&gt;C polymorphism had a protective effect against FECD (crude OR 0.51, 95% CI 0.28\u20130.92; crude OR 0.53, 95% CI 0.30\u20130.92, resp.), while the G\/C genotype and the C allele increased FECD occurrence (crude OR 1.85, 95% CI 1.01\u20133.36; crude OR 1.90, 95% CI 1.09\u20133.29, resp.).<jats:italic>Conclusions<\/jats:italic>. The c.-61T\/T and c.-98G&gt;C polymorphisms of the<jats:italic>RAD51<\/jats:italic>gene may have a role in the KC and FECD pathogenesis and can be considered as markers in these diseases.<\/jats:p>","DOI":"10.1155\/2013\/851817","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T22:36:37Z","timestamp":1380148597000},"page":"353-362","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphisms of the Homologous Recombination Gene<i>RAD51<\/i>in Keratoconus and Fuchs Endothelial Corneal Dystrophy"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-4491","authenticated-orcid":true,"given":"Ewelina","family":"Synowiec","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna A.","family":"Wojcik","sequence":"additional","affiliation":[{"name":"Department 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