{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:08:38Z","timestamp":1767236918510},"reference-count":132,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Platelets are no longer considered simply as cells participating in thrombosis. In atherosclerosis, platelets are regulators of multiple processes, with the recruitment of inflammatory cells towards the lesion sites, inflammatory mediators release, and regulation of endothelial function. The antiplatelet therapy has been used for a long time in an effort to prevent and treat cardiovascular diseases. However, limited efficacy in some patients, drug resistance, and side effects are limitations of current antiplatelet therapy. In this context, a large number of natural products (polyphenols, terpenoids, alkaloids, and fatty acids) have been reported with antiplatelet activity. In this sense, the present paper describes mechanisms of antiplatelet action of natural products on platelet P-selectin expression through cAMP levels and its role as peroxisome proliferator-activated receptors agonists.<\/jats:p>","DOI":"10.1155\/2013\/861786","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T21:22:38Z","timestamp":1384377758000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products"],"prefix":"10.1155","volume":"2013","author":[{"given":"Eduardo","family":"Fuentes","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile"},{"name":"Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001 Talca, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Palomo","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile"},{"name":"Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, R09I2001 Talca, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000087480.94275.97"},{"key":"2","first-page":"405","volume":"58","year":"2004","journal-title":"Indian Journal of Medical Sciences"},{"key":"3","first-page":"162","volume":"2","year":"2003","journal-title":"World Psychiatry"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1157\/13095778"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.CIR.97.6.596","volume":"97","year":"1998","journal-title":"Circulation"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301503"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000095974.95122.EC"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01102-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0605318"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000106320.40933.E5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2209"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.10.033"},{"key":"13","first-page":"35S","volume":"26","year":"2012","journal-title":"Journal of Biological Regulators & Homeostatic Agents"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.690113"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/nrd966"},{"issue":"2","key":"16","first-page":"179","volume":"1","year":"2008","journal-title":"Molecular Medicine Reports"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.151"},{"key":"18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/HCO.0b013e328356ae95","volume":"27","year":"2012","journal-title":"Current Opinion in Cardiology"},{"key":"19","year":"2013","journal-title":"Vascular Pharmacology"},{"key":"20","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","volume":"368","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92580-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-011-0269-4"},{"key":"23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jff.2012.08.007","volume":"5","year":"2013","journal-title":"Journal of Functional Foods"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2008.09.012"},{"key":"25","doi-asserted-by":"crossref","first-page":"11526","DOI":"10.3390\/molecules180911526","volume":"18","year":"2013","journal-title":"Molecules"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100135"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.08.007"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01825.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/136584"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02385-7"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711875105"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306981100"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-200108000-00002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/35013000"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.09.001"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147614.85888.7A"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0926"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200620040-00004"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.183160"},{"issue":"1","key":"40","first-page":"425","volume":"287","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.193367"},{"issue":"2","key":"42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-0037-1613448","volume":"89","year":"2003","journal-title":"Thrombosis and Haemostasis"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00452-4"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009217200"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1058"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-052522"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.12.028"},{"issue":"3","key":"48","first-page":"488","volume":"88","year":"2002","journal-title":"Thrombosis and Haemostasis"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1080\/09537109876537"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139338.12464.5F"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809780200"},{"key":"52","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1160\/TH12-06-0397","volume":"108","year":"2012","journal-title":"Thrombosis and Haemostasis"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00405-X"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1080\/09537100902912451"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0526"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03401.x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.064"},{"key":"58","doi-asserted-by":"crossref","first-page":"544S","DOI":"10.1093\/ajcn\/78.3.544S","volume":"78","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32834d78dd"},{"issue":"7","key":"60","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/jn\/136.7.1886","volume":"136","year":"2006","journal-title":"Journal of Nutrition"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1080\/09537100500129540"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328343f7da"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1080\/09537100410001710290"},{"issue":"7","key":"64","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/01.mbc.0000184737.50594.a8","volume":"16","year":"2005","journal-title":"Blood Coagulation and Fibrinolysis"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1159\/000097696"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024062330700"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60380"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1021\/jf062587s"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1159\/000337380"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/683872"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01099.x"},{"key":"72","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.3390\/molecules18078120","volume":"18","year":"2013","journal-title":"Molecules"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.07.009"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/147031"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700507"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00412-1"},{"issue":"8","key":"107","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1172\/JCI635","volume":"101","year":"1998","journal-title":"Journal of Clinical Investigation"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1021\/jf0628835"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2782com"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.097337"},{"issue":"7","key":"100","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1016\/j.bmcl.2012.02.002","volume":"22","year":"2012","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.11.073"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.12.0016"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00206-3"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(95)90040-3"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00813.x"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000221921.71300.BF"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051643"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1021\/jf051352y"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90295-T"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.5551\/jat.10363"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1021\/jf0500738"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90107-4"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.10.011"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707367"},{"key":"82","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bcp.2012.06.022","volume":"84","year":"2012","journal-title":"Biochemical Pharmacology"},{"key":"132","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.taap.2012.06.021","volume":"263","year":"2012","journal-title":"Toxicology and Applied Pharmacology"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/485262"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.05.023"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.10.009"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-18-93"},{"key":"117","year":"2012","journal-title":"Journal of Nutritional Biochemistry"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-09-0636"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1021\/jf103940u"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1021\/jf101518p"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1331.022"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-3-25"},{"issue":"10","key":"89","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.94.10.2434","volume":"94","year":"1996","journal-title":"Circulation"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134485.30393.63"},{"issue":"1","key":"73","doi-asserted-by":"crossref","first-page":"36","DOI":"10.7326\/0003-4819-129-1-199807010-00008","volume":"129","year":"1998","journal-title":"Annals of Internal Medicine"},{"key":"74","year":"2007"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2007.00606.x"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02390-6"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306238200"},{"issue":"3","key":"79","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jps.2600670319","volume":"67","year":"1978","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1021\/np800494e"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.04.001"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.226118"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.854"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1021\/jf9018382"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.2174\/092986610792231537"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151307.10576.02"},{"issue":"2","key":"102","first-page":"238","volume":"337","year":"1988","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj063"},{"key":"108","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/MBC.0b013e3283570846","volume":"23","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn282"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1260"},{"issue":"1","key":"113","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/bj3280013","volume":"328","year":"1997","journal-title":"Biochemical Journal"},{"issue":"5","key":"114","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1085\/jgp.66.5.561","volume":"66","year":"1975","journal-title":"Journal of General Physiology"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1159\/000337182"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03769.x"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.241067"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/861786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/861786.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/861786.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T07:05:11Z","timestamp":1647068711000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/861786\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":132,"alternative-id":["861786","861786"],"URL":"https:\/\/doi.org\/10.1155\/2013\/861786","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}