{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:11:34Z","timestamp":1784034694499,"version":"3.55.0"},"reference-count":86,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Both ankylosing spondylitis (AS) and Crohn\u2019s disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen,<jats:italic>Klebsiella pneumoniae<\/jats:italic>, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the<jats:italic>Klebsiella<\/jats:italic>microbes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-<jats:italic>Klebsiella<\/jats:italic>antibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.<\/jats:p>","DOI":"10.1155\/2013\/872632","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T21:02:31Z","timestamp":1369688551000},"page":"1-9","source":"Crossref","is-referenced-by-count":50,"title":["The Link between Ankylosing Spondylitis, Crohn\u2019s Disease,<i>Klebsiella<\/i>, and Starch Consumption"],"prefix":"10.1155","volume":"2013","author":[{"given":"Taha","family":"Rashid","sequence":"first","affiliation":[{"name":"Analytical Sciences Group, Kings College, 150 Stamford Street, London SE1 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clyde","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Kings 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