{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:22:48Z","timestamp":1791285768809,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Growing evidence suggests that the patient\u2019s immune response may play a major role in the long-term efficacy of antibody therapies of follicular lymphoma (FL). Particular long-lasting recurrence free survivals have been observed after first line, single agent rituximab or after radioimmunotherapy (RIT). Rituximab maintenance, furthermore, has a major efficacy in prolonging recurrence free survival after chemotherapy. On the other hand, RIT as a single step treatment showed a remarkable capacity to induce complete and partial remissions when applied in recurrence and as initial treatment of FL or given for consolidation. These clinical results strongly suggest that RIT combined with rituximab maintenance could stabilize the high percentages of patients with CR and PR induced by RIT. While the precise mechanisms of the long-term efficacy of these 2 treatments are not elucidated, different observations suggest that the patient\u2019s T cell immune response could be decisive. With this review, we discuss the potential role of the patient\u2019s immune system under rituximab and RIT and argue that the T cell immunity might be particularly promoted when combining the 2 antibody treatments in the early therapy of FL.<\/jats:p>","DOI":"10.1155\/2013\/875343","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T21:31:38Z","timestamp":1385501498000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Radioimmunotherapy Combined with Maintenance Anti-CD20 Antibody May Trigger Long-Term Protective T Cell Immunity in Follicular Lymphoma Patients"],"prefix":"10.1155","volume":"2013","author":[{"given":"Franz","family":"Buchegger","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland"},{"name":"Department of Nuclear Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Mach","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne, 1066 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-8104","authenticated-orcid":true,"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[{"name":"Department of Hematology, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cairoli","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lausanne University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Prior","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Romero","sequence":"additional","affiliation":[{"name":"Ludwig Center, Department of Oncology, Lausanne University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-3250","authenticated-orcid":true,"given":"Daniel E.","family":"Speiser","sequence":"additional","affiliation":[{"name":"Ludwig Center, Department of Oncology, Lausanne University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"13","key":"1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s40265-013-0092-5","volume":"73","year":"2013","journal-title":"Drugs"},{"key":"2","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1182\/blood-2012-03-417808","volume":"119","year":"2012","journal-title":"Blood"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.054"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq287"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07886.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310213291702"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308123290703"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3411"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.4786"},{"key":"10","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1093\/annonc\/mds177","volume":"23","year":"2012","journal-title":"Annals of Oncology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.052"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041511"},{"key":"13","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1182\/blood.V114.22.3759.3759","volume":"114","year":"2009","journal-title":"Blood"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6258"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.087460"},{"key":"16","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/annonc\/mdt198","volume":"24","year":"2013","journal-title":"Annals of Oncology"},{"key":"17","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1038\/bcj.2011.53","volume":"2","year":"2012","journal-title":"Blood Cancer Journal"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370908"},{"key":"19","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1172\/JCI63186","volume":"122","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"20","first-page":"109","volume":"13","year":"2013","journal-title":"The Ochsner Journal"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-345777"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-377283"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701665954"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05137.x"},{"key":"25","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1172\/JCI64859","volume":"123","year":"2013","journal-title":"Journal of Clinical Investigation"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46102"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59806"},{"key":"28","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","volume":"351","year":"2004","journal-title":"The New England Journal of Medicine"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-115915"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-018218"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-4-50"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.08.001"},{"key":"33","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.4049\/jimmunol.1201363","volume":"190","year":"2013","journal-title":"The Journal of Immunology"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59266"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.4623"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1339"},{"key":"37","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1182\/blood-2012-04-421826","volume":"121","year":"2013","journal-title":"Blood"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.3685"},{"key":"39","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","year":"2010","journal-title":"The New England Journal of Medicine"},{"key":"40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1302369","volume":"369","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"41","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","volume":"366","year":"2012","journal-title":"The New England Journal of Medicine"},{"key":"42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJMoa1305133","volume":"369","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"43","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1182\/blood-2012-06-432443","volume":"121","year":"2013","journal-title":"Blood"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60251-8"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015463811683"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-201988"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-185280"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-248609"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e31819b7c17"},{"key":"50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2249.2012.04658.x","volume":"170","year":"2012","journal-title":"Clinical and Experimental Immunology"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-223263"},{"key":"52","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2012-05-432393","volume":"121","year":"2013","journal-title":"Blood"},{"key":"53","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.3109\/10428194.2013.769219","volume":"54","year":"2013","journal-title":"Leukemia & Lymphoma"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07773.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0815"},{"key":"56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0140-6736(10)62175-7","volume":"377","year":"2011","journal-title":"The Lancet"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-351411"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0264"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi320"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-340646"},{"key":"61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/cmi.2012.39","volume":"10","year":"2013","journal-title":"Cellular & Molecular Immunology"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901980"},{"key":"63","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1002\/ijc.23365","volume":"122","year":"2008","journal-title":"International Journal of Cancer"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-172296"},{"key":"65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11899-012-0133-2","volume":"7","year":"2012","journal-title":"Current Hematologic Malignancy Reports"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22617"},{"key":"67","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1200\/JCO.2011.41.1553","volume":"31","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.2015"},{"key":"69","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1200\/JCO.2012.45.6400","volume":"31","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"70","volume":"118, abstract 2701","year":"2011","journal-title":"Blood"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603166"},{"key":"72","first-page":"A114","volume":"52","year":"2013","journal-title":"Nuclear Medicine"},{"issue":"2","key":"73","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.167.2.345","volume":"167","year":"1988","journal-title":"Journal of Experimental Medicine"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5376"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153189"},{"key":"78","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1200\/JCO.2012.47.7315","volume":"31","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"79","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0140-6736(12)61763-2","volume":"381","year":"2013","journal-title":"The Lancet"},{"key":"80","volume":"120, abstract 902","year":"2012","journal-title":"Blood"},{"key":"81","volume":"120, abstract 3681","year":"2012","journal-title":"Blood"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.076"},{"key":"83","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1200\/JCO.2012.42.4101","volume":"31","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"84","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/annonc\/mds517","volume":"24","year":"2013","journal-title":"Annals of Oncology"},{"key":"85","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ajh.23372","volume":"88","year":"2013","journal-title":"American Journal of Hematology"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08969.x"},{"key":"87","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.clml.2012.12.011","volume":"13","year":"2013","journal-title":"Clinical Lymphoma Myeloma and Leukemia"},{"key":"88","first-page":"980","volume":"2","year":"2010","journal-title":"Frontiers in Bioscience"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-008-0018-1"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3687"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.02.006"},{"key":"92","volume":"120, abstract 3019","year":"2012","journal-title":"Blood"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4690"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.043"},{"key":"95","volume":"120, abstract 4882","year":"2012","journal-title":"Blood"},{"key":"96","volume":"2012, abstract 4924","year":"2012","journal-title":"Blood"},{"issue":"11","key":"97","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.3109\/10428194.2013.781169","volume":"54","year":"2013","journal-title":"Leukemia & Lymphoma"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-149161"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-296913"},{"key":"100","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1093\/annonc\/mdr620","volume":"23","year":"2012","journal-title":"Annals of Oncology"},{"key":"101","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1002\/cncr.28299","volume":"119","year":"2013","journal-title":"Cancer"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372649"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174839"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/875343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/875343.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/875343.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T20:42:00Z","timestamp":1597092120000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2013\/875343\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":103,"alternative-id":["875343","875343"],"URL":"https:\/\/doi.org\/10.1155\/2013\/875343","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"value":"1740-2522","type":"print"},{"value":"1740-2530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}