{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:53:39Z","timestamp":1773842019522,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["ART56-NMC-704763"],"award-info":[{"award-number":["ART56-NMC-704763"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Haptic robots allow the exploitation of known motorlearning mechanisms, representing a valuable option for motor treatment after stroke. The aim of this feasibility multicentre study was to test the clinical efficacy of a haptic prototype, for the recovery of hand function after stroke.<jats:italic>Methods<\/jats:italic>. A prospective pilot clinical trial was planned on 15 consecutive patients enrolled in 3 rehabilitation centre in Italy. All the framework features of the haptic robot (e.g., control loop, external communication, and graphic rendering for virtual reality) were implemented into a real-time MATLAB\/Simulink environment, controlling a five-bar linkage able to provide forces up to 20\u2009[N] at the end effector, used for finger and hand rehabilitation therapies. Clinical (i.e., Fugl-Meyer upper extremity scale; nine hold pegboard test) and kinematics (i.e., time; velocity; jerk metric; normalized jerk of standard movements) outcomes were assessed before and after treatment to detect changes in patients' motor performance. Reorganization of cortical activation was detected in one patient by fMRI.<jats:italic>Results and Conclusions<\/jats:italic>. All patients showed significant improvements in both clinical and kinematic outcomes. Additionally, fMRI results suggest that the proposed approach may promote a better cortical activation in the brain.<\/jats:p>","DOI":"10.1155\/2013\/895492","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T21:11:38Z","timestamp":1384290698000},"page":"1-12","source":"Crossref","is-referenced-by-count":44,"title":["Haptic-Based Neurorehabilitation in Poststroke Patients: A Feasibility Prospective Multicentre Trial for Robotics Hand Rehabilitation"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-8060","authenticated-orcid":true,"given":"Andrea","family":"Turolla","sequence":"first","affiliation":[{"name":"Laboratory of Kinematics and Robotics, Fondazione IRCCS, Ospedale San Camillo, Via Alberoni, Venezia Lido, 30126 Venice, Italy"},{"name":"Department of Neuroscience, University of Sheffield and Sheffield Teaching Hospital NHS Foundation Trust, Beech Hill Road, S10 2RX, Sheffield, UK"}]},{"given":"Omar A.","family":"Daud Albasini","sequence":"additional","affiliation":[{"name":"AMTC, Universidad de Chile, Avenida Tupper 2007, Edificio AMTC, Santiago, Chile"}]},{"given":"Roberto","family":"Oboe","sequence":"additional","affiliation":[{"name":"Laboratory of Kinematics and Robotics, Fondazione IRCCS, Ospedale San Camillo, Via Alberoni, Venezia Lido, 30126 Venice, Italy"},{"name":"Dipartimento di Tecnica e Gestione dei Sistemi Industriali, Universit\u00e0 di Padova Stradella S. Nicola, 36100 Vicenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-3338","authenticated-orcid":true,"given":"Michela","family":"Agostini","sequence":"additional","affiliation":[{"name":"Laboratory of Kinematics and Robotics, Fondazione IRCCS, Ospedale San Camillo, Via Alberoni, Venezia Lido, 30126 Venice, Italy"}]},{"given":"Paolo","family":"Tonin","sequence":"additional","affiliation":[{"name":"Laboratory of Kinematics and Robotics, Fondazione IRCCS, Ospedale San Camillo, Via Alberoni, Venezia Lido, 30126 Venice, Italy"}]},{"given":"Stefano","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Movement and Brain Laboratory, U.O.F. 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