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The dosage, duration, and the benefits of high-dose steroid treatment and outcome in biliary atresia (BA) remain controversial. In this study, we evaluated the impact of high-dose steroid therapy on the outcome of BA after the Kasai procedure.<jats:italic>Methods.<\/jats:italic>Intravenous prednisolone administration was started 1 week after surgery, followed by 8 to 12 weeks of oral prednisolone. Total bilirubin (TB) levels (3, 6, and 12 months after surgery), early onset of cholangitis, and two-year native liver survival were evaluated.<jats:italic>Results.<\/jats:italic>53.4%, 56.9%, and 58.1% of the patients in the high-dose steroid group were jaundice-free 3, 6, and 12 months after surgery, respectively; these values were significantly higher than the 38.7%, 39.4%, and 43.3% of the low-dose steroid group. One year after surgery, the incidence of cholangitis in the high-dose group (32.0%) was lower than that in the low-dose group (48.0%). Infants with native liver in the high-dose group had a better two-year survival compared to those in the low-dose steroid group (53.7% versus 42.6%).<jats:italic>Conclusions.<\/jats:italic>The high-dose steroid protocol can reduce the incidence of cholangitis, increase the jaundice-free rate, and improve two-year survival with native liver after the Kasai operation.<\/jats:p>","DOI":"10.1155\/2013\/902431","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T16:02:09Z","timestamp":1385308929000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-1658","authenticated-orcid":true,"given":"Rui","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Children\u2019s Hospital of Fudan University, and Key Laboratory of Neonatal Disease, 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