{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:51:50Z","timestamp":1788349910390,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretar\u00eda de Ciencia y T\u00e9cnica de la Universidad Nacional de C\u00f3rdoba"},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic<jats:italic>\u03b1<\/jats:italic>-diimine chromium(III) and ruthenium(II) complexes (where the<jats:italic>\u03b1<\/jats:italic>-diimine ligands are bpy\u2009=\u20092,2-bipyridine, phen = 1,10-phenanthroline, and dppz\u2009=\u2009dipyrido[3,2-a:2\u2032,3\u2032-c]-phenazine) like [Cr(phen)<jats:sub>3<\/jats:sub>]<jats:sup>3+<\/jats:sup>, [Cr(phen)<jats:sub>2<\/jats:sub>(dppz)]<jats:sup>3+<\/jats:sup>, [Ru(phen)<jats:sub>3<\/jats:sub>]<jats:sup>2+<\/jats:sup>, and [Ru(bpy)<jats:sub>3<\/jats:sub>]<jats:sup>2+<\/jats:sup>as antibacterial agents by generating oxidative stress. The [Cr(phen)<jats:sub>3<\/jats:sub>]<jats:sup>3+<\/jats:sup>and [Cr(phen)<jats:sub>2<\/jats:sub>(dppz)]<jats:sup>3+<\/jats:sup>complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL to 1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, while [Ru(phen)<jats:sub>3<\/jats:sub>]<jats:sup>2+<\/jats:sup>and [Ru(bpy)<jats:sub>3<\/jats:sub>]<jats:sup>2+<\/jats:sup>do not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used. When ciprofloxacin was combined with [Cr(phen)<jats:sub>3<\/jats:sub>]<jats:sup>3+<\/jats:sup>for the inhibition of<jats:italic>Staphylococcus aureus<\/jats:italic>and<jats:italic>Escherichia coli<\/jats:italic>, an important synergistic effect was observed, FIC 0.066 for<jats:italic>S. aureus<\/jats:italic>and FIC 0.064 for<jats:italic>E. coli<\/jats:italic>. The work described here shows that chromium(III) complexes are bactericidal for<jats:italic>S. aureus<\/jats:italic>and<jats:italic>E. coli<\/jats:italic>. Our results indicate that<jats:italic>\u03b1<\/jats:italic>-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.<\/jats:p>","DOI":"10.1155\/2013\/906912","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T17:04:50Z","timestamp":1378314290000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on<i>Staphylococcus aureus<\/i>and<i>Escherichia coli<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Paulina L.","family":"P\u00e1ez","sequence":"first","affiliation":[{"name":"Departamento de Farmacia, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, X5000HUA C\u00f3rdoba, 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