{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:39:32Z","timestamp":1791175172944,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["510230"],"award-info":[{"award-number":["510230"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1012413"],"award-info":[{"award-number":["1012413"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["510230"],"award-info":[{"award-number":["510230"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1012413"],"award-info":[{"award-number":["1012413"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Exclusive enteral nutrition (EEN) is a well-established approach to the management of Crohn\u2019s disease.<jats:italic>Aim<\/jats:italic>. To determine effects of EEN upon inflammation and gut barrier function in a colitis mouse model.<jats:italic>Methods<\/jats:italic>. Interleukin-10-deficient mice (IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>) were inoculated with<jats:italic>Helicobacter trogontum<\/jats:italic>and then treated with EEN, metronidazole, hydrocortisone, or EEN and metronidazole combination. Blood and tissue were collected at 2 and 4 weeks with histology, mucosal integrity, tight junction integrity, inflammation, and<jats:italic>H. trogontum<\/jats:italic>load evaluated.<jats:italic>Results<\/jats:italic>.<jats:italic>H. trogontum<\/jats:italic>induced colitis in IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>mice with histological changes in the cecum and colon. Elevated mucosal IL-8 mRNA in infected mice was associated with intestinal barrier dysfunction indicated by decreased transepithelial electrical resistance and mRNA of tight junction proteins and increased short-circuit current, myosin light chain kinase mRNA, paracellular permeability, and tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>and myeloperoxidase plasma levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>for all comparisons). EEN and metronidazole, but not hydrocortisone, treatments restored barrier function, maintained gut barrier integrity, and reversed inflammatory changes along with reduction of<jats:italic>H. trogontum<\/jats:italic>load (versus infected controls<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>.<jats:italic>H. trogontum<\/jats:italic>infection in IL-10<jats:sup>\u2212\/\u2212<\/jats:sup>mice induced typhlocolitis with intestinal barrier dysfunction. EEN and metronidazole, but not hydrocortisone, modulate barrier dysfunction and reversal of inflammatory changes.<\/jats:p>","DOI":"10.1155\/2013\/909613","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T17:01:50Z","timestamp":1375808510000},"page":"1-15","source":"Crossref","is-referenced-by-count":45,"title":["Inflammatory Bowel Disease Therapies and Gut Function in a Colitis Mouse Model"],"prefix":"10.1155","volume":"2013","author":[{"given":"Lily","family":"Nahidi","sequence":"first","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Randwick, Sydney, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Leach","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Randwick, Sydney, NSW 2031, 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