{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:49:28Z","timestamp":1792118968585,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["UH2AR057503"],"award-info":[{"award-number":["UH2AR057503"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    The human skin harbors a diverse community of bacteria, including the Gram-positive, anaerobic bacterium\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    .\n                    <jats:italic>P. acnes<\/jats:italic>\n                    has historically been linked to the pathogenesis of acne vulgaris, a common skin disease affecting over 80% of all adolescents in the US. To gain insight into potential\n                    <jats:italic>P. acnes<\/jats:italic>\n                    pathogenic mechanisms, we previously sequenced the complete genome of a\n                    <jats:italic>P. acnes<\/jats:italic>\n                    strain HL096PA1 that is highly associated with acne. In this study, we compared its genome to the first published complete genome KPA171202. HL096PA1 harbors a linear plasmid, pIMPLE-HL096PA1. This is the first described\n                    <jats:italic>P. acnes<\/jats:italic>\n                    plasmid. We also observed a five-fold increase of pseudogenes in HL096PA1, several of which encode proteins in carbohydrate transport and metabolism. In addition, our analysis revealed a few island-like genomic regions that are unique to HL096PA1 and a large genomic inversion spanning the ribosomal operons. Together, these findings offer a basis for understanding\n                    <jats:italic>P. acnes<\/jats:italic>\n                    virulent properties, host adaptation mechanisms, and its potential role in acne pathogenesis at the strain level. Furthermore, the plasmid identified in HL096PA1 may potentially provide a new opportunity for\n                    <jats:italic>P. acnes<\/jats:italic>\n                    genetic manipulation and targeted therapy against specific disease-associated strains.\n                  <\/jats:p>","DOI":"10.1155\/2013\/918320","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T17:04:28Z","timestamp":1368464668000},"page":"1-11","source":"Crossref","is-referenced-by-count":68,"title":["Analysis of Complete Genomes of\n                    <i>Propionibacterium acnes<\/i>\n                    Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain"],"prefix":"10.1155","volume":"2013","author":[{"given":"Gabriela","family":"Kasimatis","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorel","family":"Fitz-Gibbon","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuta","family":"Tomida","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthew","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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