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Five groups of male<jats:italic>Sprague Dawley<\/jats:italic>have been used. In group 1 rats received intraperitoneal (i.p.) injection of normal saline while groups 2\u20135 received thioacetamide (TAA, 200\u2009mg\/kg; i.p.) for induction of liver cirrhosis, thrice weekly for eight weeks. Group 3 received 50\u2009mg\/kg of silymarin. The rats in groups 4 and 5 received 250 and 500\u2009mg\/kg of ERZO (dissolved in 10% Tween), respectively. Hepatic damage was assessed grossly and microscopically for all of the groups. Results confirmed the induction of liver cirrhosis in group 2 whilst administration of silymarin or ERZO significantly reduced the impact of thioacetamide toxicity. These groups decreased fibrosis of the liver tissues. Immunohistochemistry assessment against proliferating cell nuclear antigen did not show remarkable proliferation in the ERZO-treated rats when compared with group 2. Moreover, factions of the ERZO extract were tested on Hep-G2 cells and showed antiproliferative activity (IC<jats:sub>50<\/jats:sub>38\u201360\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). This study showed hepatoprotective effect of ERZO.<\/jats:p>","DOI":"10.1155\/2013\/918460","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T21:03:56Z","timestamp":1386882236000},"page":"1-10","source":"Crossref","is-referenced-by-count":32,"title":["<i>In Vivo<\/i>Evaluation of Ethanolic Extract of<i>Zingiber officinale<\/i>Rhizomes for Its Protective Effect against Liver Cirrhosis"],"prefix":"10.1155","volume":"2013","author":[{"given":"Daleya","family":"Abdulaziz Bardi","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Farouq","family":"Halabi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor 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