{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:36:35Z","timestamp":1770413795031,"version":"3.49.0"},"reference-count":40,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Research Funding of Satakunta Central Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Molecular Imaging"],"published-print":{"date-parts":[[2013,1,21]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We compared five parathyroid scintigraphy protocols in patients with primary (pHPT) and secondary hyperparathyroidism (sHPT) and studied the interobserver agreement. The dual-tracer method (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi\/<jats:sup>123<\/jats:sup>I) was used with three acquisition techniques (parallel-hole planar, pinhole planar, and SPECT\/CT). The single-tracer method (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi) was used with two acquisition techniques (double-phase parallel-hole planar, and SPECT\/CT). Thus five protocols were used, resulting in five sets of images. \n<jats:italic>Materials and Methods<\/jats:italic>. Image sets of 51 patients were retrospectively graded by four experienced nuclear medicine physicians. The final study group consisted of 24 patients (21 pHPT, 3 sHPT) who had been operated upon.  Surgical and histopathologic findings were used as the standard of comparison. <jats:italic>Results<\/jats:italic>. Thirty abnormal parathyroid glands were found in 24 patients. The sensitivities of the dual-tracer method (76.7\u201380.0%) were similar (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1.0<\/mml:mn><\/mml:mrow><\/mml:math>). The sensitivities of the single-tracer method (13.3\u201331.6%) were similar (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.625<\/mml:mn><\/mml:mrow><\/mml:math>). All differences in sensitivity between these two methods were statistically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.012<\/mml:mn><\/mml:mrow><\/mml:math>). The interobserver agreement was good. <jats:italic>Conclusion<\/jats:italic>. This study indicates that any dual-tracer protocol with <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi and <jats:sup>123<\/jats:sup>I is superior for enlarged parathyroid gland localization when compared with single-tracer protocols using <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mtext>m<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>c-sestamibi alone. The parathyroid scintigraphy was found to be independent of the reporter.<\/jats:p>","DOI":"10.1155\/2013\/921260","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:06:31Z","timestamp":1358802391000},"page":"1-12","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of Five Parathyroid Scintigraphic Protocols"],"prefix":"10.1155","volume":"2013","author":[{"given":"Virpi","family":"Tunninen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500 Pori, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Varjo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Satakunta Central Hospital, Sairaalantie 3, 28500 Pori, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Schildt","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, HUS, P.O. 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