{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:31:01Z","timestamp":1791178261887,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["FWO G.0707.09"],"award-info":[{"award-number":["FWO G.0707.09"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Gold- (Au-) based nanomaterials have shown promising potential in nanomedicine. The individual health status is an important determinant of the response to injury\/exposure. It is, therefore, critical to evaluate exposure to Au-nanomaterials with varied preexisting health status.<jats:italic>Objective<\/jats:italic>. The goal of this research was to determine the extent of extrapulmonary translocation from healthy and inflamed lungs after pulmonary exposure to AuNPs. Male BALB\/c mice received a single dose of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>0.8<\/mml:mn><mml:mtext>\u2009mg<\/mml:mtext><mml:mo>\u00b7<\/mml:mo><mml:msup><mml:mtext>kg<\/mml:mtext><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>AuNPs (40\u2009nm) by oropharyngeal aspiration 24 hours after priming with LPS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>0.4<\/mml:mn><mml:mtext>\u2009mg<\/mml:mtext><mml:mo>\u00b7<\/mml:mo><mml:msup><mml:mtext>kg<\/mml:mtext><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>) through the same route. Metal contents were analyzed in different organs by inductively coupled plasma-mass spectrometry (ICP-MS).<jats:italic>Results<\/jats:italic>. Oropharyngeal aspiration resulted in high metal concentrations in lungs (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>); however, these were much lower after pretreatment with LPS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Significantly higher concentrations of Au were detected in heart and thymus of healthy animals, whereas higher concentrations of Au NPs were observed in spleen in LPS-primed animals.<jats:italic>Conclusions<\/jats:italic>. The distribution of AuNPs from lungs to secondary target organs depends upon the health status, indicating that targeting of distinct secondary organs in nanomedicine needs to be considered carefully under health and inflammatory conditions.<\/jats:p>","DOI":"10.1155\/2013\/923475","type":"journal-article","created":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T16:00:50Z","timestamp":1358092850000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["Prior Lung Inflammation Impacts on Body Distribution of Gold Nanoparticles"],"prefix":"10.1155","volume":"2013","author":[{"given":"Salik","family":"Hussain","sequence":"first","affiliation":[{"name":"Laboratory of Molecular and Cellular Responses to Xenobiotics, CNRS EAC 7059, Unit of Functional and Adaptive Biology (BFA), Sorbonne Paris Cit\u00e9, University of Paris Diderot, 75 013 Paris, France"},{"name":"Lung Toxicology Research Unit, KU Leuven, 3000 Leuven, Belgium"},{"name":"Clinical Research Unit, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, North Carolina NC 27709, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A. J.","family":"Vanoirbeek","sequence":"additional","affiliation":[{"name":"Lung Toxicology Research Unit, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Haenen","sequence":"additional","affiliation":[{"name":"Lung Toxicology Research Unit, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Haufroid","sequence":"additional","affiliation":[{"name":"Louvain Centre for Toxicology and Applied Pharmacology, Catholic University of Louvain, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Boland","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Responses to Xenobiotics, CNRS EAC 7059, Unit of Functional and Adaptive Biology (BFA), Sorbonne Paris Cit\u00e9, University of Paris Diderot, 75 013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francelyne","family":"Marano","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Responses to Xenobiotics, CNRS EAC 7059, Unit of Functional and Adaptive Biology (BFA), Sorbonne Paris Cit\u00e9, University of Paris Diderot, 75 013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Nemery","sequence":"additional","affiliation":[{"name":"Lung Toxicology Research Unit, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. M.","family":"Hoet","sequence":"additional","affiliation":[{"name":"Lung Toxicology Research Unit, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2165\/11534450-000000000-00000"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.06.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791110827"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2010.58"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914561107"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1039\/b913224d"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1039\/b712170a"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200400093"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200700378"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.104118"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-865OC"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00103805"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153X-3-16"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/08958370902942517"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2007.10.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00108603"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.05.022"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.166"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1100\/2011\/768350"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8903"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.05.014"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/08958370600748281"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00168509"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.122"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-4-10"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1080\/17435390701763108"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.11.079"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio773"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1039\/c2nr31185b"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/923475.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/923475.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/923475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T23:32:52Z","timestamp":1471563172000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/923475\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":29,"alternative-id":["923475","923475"],"URL":"https:\/\/doi.org\/10.1155\/2013\/923475","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}