{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:47:34Z","timestamp":1763747254001,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University Science Malaysia","award":["1001\/PSK\/8620012","311.CIPPM.4401005"],"award-info":[{"award-number":["1001\/PSK\/8620012","311.CIPPM.4401005"]}]},{"name":"University Science Malaysia","award":["1001\/PSK\/8620012","311.CIPPM.4401005"],"award-info":[{"award-number":["1001\/PSK\/8620012","311.CIPPM.4401005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The synthesized compounds were screened for their antimycobacterial activity against<jats:italic>M. tuberculosis<\/jats:italic>H<jats:sub>37<\/jats:sub>Rv (MTB-H<jats:sub>37<\/jats:sub>Rv) and INH-resistant<jats:italic>M. tuberculosis<\/jats:italic>(INHR-MTB) strains using agar dilution method. Three of them displayed good activity with MIC of less than 0.2\u2009<jats:italic>\u03bc<\/jats:italic>M. Compound ethyl 1-(2-(4-(4-(ethoxycarbonyl)-2-aminophenyl)piperazin-1-yl)ethyl)-2-(4-(5-(4-fluorophenyl)pyridin-3-ylphenyl-1H-benzo[d]imidazole-5-carboxylate (<jats:bold>5g<\/jats:bold>) was found to be the most active with MIC of 0.112\u2009<jats:italic>\u03bc<\/jats:italic>M against MTB-H<jats:sub>37<\/jats:sub>Rv and 6.12\u2009<jats:italic>\u03bc<\/jats:italic>M against INHR-MTB, respectively.<\/jats:p>","DOI":"10.1155\/2013\/926309","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T16:15:44Z","timestamp":1386260144000},"page":"1-6","source":"Crossref","is-referenced-by-count":19,"title":["Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives"],"prefix":"10.1155","volume":"2013","author":[{"given":"Yeong","family":"Keng Yoon","sequence":"first","affiliation":[{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ashraf Ali","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia"},{"name":"New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301030, India"},{"name":"New Drug Discovery Research, Department of Medicinal Chemistry, Sunrise University, Alwar, Rajasthan 301030, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan Soo","family":"Choon","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusli","family":"Ismail","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Research in AIDS (CERiA), University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Chee Wei","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Suresh Kumar","sequence":"additional","affiliation":[{"name":"School of Chemical Science, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia"},{"name":"Department of Chemistry, College of Science, King Saud University, P.O. 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