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The mechanism of action of lenalidomide varies depending on the pathology, and in the case of CLL, it appears to primarily act by restoring the damaged mechanisms of tumour immunosurveillance. This review discusses the potential mechanism of action and efficacy of lenalidomide, alone or in combination, in treatment of CLL and its toxic effects such as tumor lysis syndrome (TLS) and tumor flare reaction (TFR), that make its management different from other hematologic malignancies.<\/jats:p>","DOI":"10.1155\/2013\/932010","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:49:08Z","timestamp":1379638148000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["Lenalidomide and Chronic Lymphocytic Leukemia"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ana Pilar","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Hematology, Hospital Universitario Central de Asturias, C\/Celestino Villamil s\/n, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel R.","family":"Payer","sequence":"additional","affiliation":[{"name":"Department of 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