{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:45:08Z","timestamp":1773236708925,"version":"3.50.1"},"reference-count":17,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Gastrointestinal stromal tumors or \u201cGIST\u201d are mesenchymal neoplasms expressing KIT(CD117) tyrosine kinase and showing the presence of activating mutations in KIT or<jats:italic>PDGFR<jats:italic>\u03b1<\/jats:italic><\/jats:italic>(platelet-derived growth factor alpha). GIST of anal canal is an extremely rare tumor, accounting for only 3% of all anorectal mesenchymal tumors and 0.1\u20130.4% of all GIST. GIST with large tumor size and high mitotic activity are highly malignant, but the biological behavior of anorectal GIST is less clear. Abdominoperineal resection (APR) or conservative surgery is the best treatment option. Imatinib mesylate, a tyrosine kinase inhibitor, has shown promising results in its management. We present a case of anorectal GIST diagnosed by computed tomography (CT) scan, magnetic resonance imaging (MRI), and colonoscopy with biopsy. The patient underwent abdominoperineal resection (APR) and was confirmed on histopathology to have anal canal GIST with tumor size more than 5\u2009cm in maximum dimension and mitotic figures more than 5\/50 high power field (HPF). The CD117\u2014immunoreactive score\u2014was 3+ in spindled cells. Therefore the patient was put on adjuvant imatinib mesylate 400\u2009mg daily.<\/jats:p>","DOI":"10.1155\/2013\/934875","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T17:04:51Z","timestamp":1364231091000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["Anorectal Gastrointestinal Stromal Tumor: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2013","author":[{"given":"Sanjeev","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Surgery, Northern Railway Central Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Radiology, ESI Model Hospital and PGIMSR, Basaidarapur, New Delhi 110001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Tugnait","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northern 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