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The common toads have lately been divided into two genera: <jats:italic>Bufo<\/jats:italic> (Europe, Asia, and Africa) and <jats:italic>Rhinella<\/jats:italic> (South America). Basal <jats:italic>Rhaebo<\/jats:italic> genus is exclusively of Central America and Amazon region. Although <jats:italic>Rhinella<\/jats:italic> and <jats:italic>Rhaebo<\/jats:italic> are related, species may share differences due to the diversity of environments that they live in. In this work, we have performed a biochemical characterization of the components of the poison of eight <jats:italic>Rhinella<\/jats:italic> species and one <jats:italic>Rhaebo<\/jats:italic> by means of RP\u2010HPLC with either UV or MS detection and by SDS\u2010PAGE, in order to verify whether phylogenetic and biological differences, such as habitat, diet, and defensive strategies, between them may also be reflected in poison composition. Although some components were common among the secretions, we were able to identify exclusive molecules to some species. The fact that closely related animals living in different habitats secrete different molecules into the skin is an indication that biological features, and not only evolution, seem to directly influence the skin secretion composition.<\/jats:p>","DOI":"10.1155\/2013\/937407","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:27:27Z","timestamp":1367454447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Differences and Similarities among Parotoid Macrogland Secretions in South American Toads: A Preliminary Biochemical Delineation"],"prefix":"10.1155","volume":"2013","author":[{"given":"Juliana Mozer","family":"Sciani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Blanes","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta M.","family":"Antoniazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Jared","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Carvalho","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(95)98515-I"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.03.029"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(03)00022-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-007-9261-x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0580560"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.583"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4436"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1989"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.05.008"},{"key":"e_1_2_7_10_2","first-page":"579","article-title":"Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development","volume":"45","author":"Gomes A.","year":"2007","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.100.127"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88605-8"},{"key":"e_1_2_7_13_2","first-page":"175","article-title":"Contribui\u00e7\u00e3o ao estudo do veneno de batr\u00e1chios do g\u00eanero Bufo","volume":"39","author":"Brazil V.","year":"1925","journal-title":"Brazil-Medico"},{"key":"e_1_2_7_14_2","article-title":"Bufo marinus (Cane Toad) predation","volume":"24","author":"Garrett C. 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