{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:20:48Z","timestamp":1774624848908,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54 HL090503"],"award-info":[{"award-number":["1U54 HL090503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1U54 HL090503"],"award-info":[{"award-number":["1U54 HL090503"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD). Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-\/autoantibodies, while others do not in a similar multiple transfusional setting, we investigated a possible genetic basis for alloimmunization. Biomarker(s) which predicts (predict) susceptibility to alloimmunization could identify patients at risk before the onset of a transfusion program and thus may have important implications for clinical management. In addition, such markers could shed light on the mechanism(s) underlying alloimmunization. We genotyped 27 single nucleotide polymorphisms (SNPs) in the<jats:italic>CD81<\/jats:italic>,<jats:italic>CHRNA10,<\/jats:italic>and<jats:italic>ARHG<\/jats:italic>genes in two groups of SCD patients. One group (35) of patients developed alloantibodies, and another (40) had no alloantibodies despite having received multiple transfusions. Two SNPs in the<jats:italic>CD81<\/jats:italic>gene, that encodes molecule involved in the signal modulation of B lymphocytes, show a strong association with alloimmunization. If confirmed in prospective studies with larger cohorts, the two SNPs identified in this retrospective study could serve as predictive biomarkers for alloimmunization.<\/jats:p>","DOI":"10.1155\/2013\/937846","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T21:27:32Z","timestamp":1369258052000},"page":"1-9","source":"Crossref","is-referenced-by-count":33,"title":["The Association of<i>CD81<\/i>Polymorphisms with Alloimmunization in Sickle Cell Disease"],"prefix":"10.1155","volume":"2013","author":[{"given":"Zohreh","family":"Tatari-Calderone","sequence":"first","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children\u2019s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970, USA"},{"name":"Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryad","family":"Tamouza","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Department and INSERM, UMRS 940, Saint Louis Hospital, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gama P.","family":"Le Bouder","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children\u2019s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramita","family":"Dewan","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children\u2019s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi L. 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