{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:18:59Z","timestamp":1793387939405,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Pesquisa"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE<jats:sub>2<\/jats:sub>and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE<jats:sub>2<\/jats:sub>in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged<jats:italic>in vitro<\/jats:italic>with Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE<jats:sub>2<\/jats:sub><jats:italic>in vivo<\/jats:italic>in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.<\/jats:p>","DOI":"10.1155\/2013\/947687","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T21:01:46Z","timestamp":1388005306000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E<sub>2<\/sub>and Nitric Oxide during Experimental Murine Paracoccidioidomycosis"],"prefix":"10.1155","volume":"2013","author":[{"given":"S. C.","family":"Sargi","sequence":"first","affiliation":[{"name":"Department of Agricultural Sciences-Food Science, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M. O.","family":"Dalalio","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E. L.","family":"Visentainer","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Visentainer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maringa, Avenida Colombo 5.790, 87.020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-179"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89132011000200012"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/1438-9312(200101)103:1<45::AID-EJLT45>3.0.CO;2-9","volume":"103","year":"2001","journal-title":"European Journal of Lipid Science and Technology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928178"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.60.7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00576-7"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343s","volume":"71","year":"2000","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"7","key":"8","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/jn\/135.7.1745","volume":"135","year":"2005","journal-title":"Journal of Nutrition"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-007-3081-1"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.6.2.89","volume":"6","year":"1993","journal-title":"Clinical Microbiology Reviews"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1063857"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.11.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2546-2552.2000"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762012000300003"},{"key":"15","year":"1995"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.200700040"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-011-0002-x"},{"issue":"8","key":"18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","volume":"37","year":"1959","journal-title":"Canadian Journal of Biochemistry and Physiology"},{"key":"19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/jaoac\/75.3.488","volume":"75","year":"1992","journal-title":"Journal of AOAC International"},{"key":"20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1590\/S0100-40422012000200008","volume":"35","year":"2012","journal-title":"Quimica Nova"},{"key":"21","first-page":"177","volume":"11","year":"1969","journal-title":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"},{"issue":"9","key":"22","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.4049\/jimmunol.168.9.4593","volume":"168","year":"2002","journal-title":"Journal of Immunology"},{"key":"23","year":"2007"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665107005472"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9301-x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02326.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00232-07"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.02.019"},{"issue":"6","key":"29","doi-asserted-by":"crossref","first-page":"1505S","DOI":"10.1093\/ajcn\/83.6.1505S","volume":"83","year":"2006","journal-title":"The American Journal of Clinical Nutrition"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2007.10.015"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-52732010000600013"},{"issue":"11","key":"32","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1590\/S0100-879X2000001100001","volume":"33","year":"2000","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"33","first-page":"135","volume":"8","year":"2006","journal-title":"Revista Mn-Metab\u00f3lica"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.10.010"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-9065-0"},{"issue":"5","key":"36","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/ajcn\/77.5.1287","volume":"77","year":"2003","journal-title":"The American Journal of Clinical Nutrition"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/947687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/947687.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/947687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T21:57:44Z","timestamp":1597269464000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/947687\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":36,"alternative-id":["947687","947687"],"URL":"https:\/\/doi.org\/10.1155\/2013\/947687","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}