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Lapachol [2-hydroxy-3-(3\u2032-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens. In this study, using the classic microscopic<jats:italic>in vitro<\/jats:italic>model, we have analyzed the effects of a series of lapachol and chlorides complexes with antimony (V), bismuth (V), and tin (IV) against<jats:italic>L. amazonensis<\/jats:italic>. All seven compounds exhibited antileishmanial activity, but most of the antimony (V) and bismuth (V) complexes were toxic against human HepG2 cells and murine macrophages. The best IC<jats:sub>50<\/jats:sub>values (0.17<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo>\u00b1<\/mml:mo><\/mml:mrow><\/mml:math>0.03 and 0.10<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo>\u00b1<\/mml:mo><\/mml:mrow><\/mml:math>0.11\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03bc<\/mml:mi><\/mml:mrow><\/mml:math>g\/mL) were observed for Tin (IV) complexes (<jats:bold>3<\/jats:bold>) [(Lp)(Ph<jats:sub>3<\/jats:sub>Sn)] and (<jats:bold>6<\/jats:bold>) (Ph<jats:sub>3<\/jats:sub>SnCl<jats:sub>2<\/jats:sub>), respectively. Their selective indexes (SIs) were 70.65 and 120.35 for HepG2 cells, respectively. However, while analyzing murine macrophages, the SI decreased. Those compounds were moderately toxic for HepG2 cells and toxic for murine macrophages, still underlying the need of chemical modification in this class of compounds.<\/jats:p>","DOI":"10.1155\/2013\/961783","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T17:00:39Z","timestamp":1369501239000},"page":"1-7","source":"Crossref","is-referenced-by-count":37,"title":["Cytotoxicity and<i>In Vitro<\/i>Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol"],"prefix":"10.1155","volume":"2013","author":[{"given":"Marcele Neves","family":"Rocha","sequence":"first","affiliation":[{"name":"Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz\/FIOCRUZ, 30190-002 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Monalisa","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo 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