{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:30:12Z","timestamp":1770438612445,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Activin A as a predictor of pregnancy failure has been the focus of heated debate, but the value of a combined activin A and follistatin (FS) measurement in serum to predict pregnancy failure has not been reported yet. We assessed whether a single serum measurement of the two physiological antagonists at 6\u20138 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP ( = 30, median value of 264\u2009pg\/mL) and women with MA ( = 30, median value of 350\u2009pg\/mL) compared to IUP ( = 33, median value of 788\u2009pg\/mL); . At a threshold value of 505\u2009pg\/mL, activin A had 87.9% sensitivity and 100% specificity and negative predictive value of 0.974 for discriminating an ectopic pregnancy from viable pregnancies. FS was able to discriminate IUP from EP (ROC curve ) as was their ratio (ROC curve ), but was unable to discriminate a MA from an EP. In EP, activin A did not correlate with beta HCG levels. The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP).<\/jats:p>","DOI":"10.1155\/2013\/969473","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T17:04:32Z","timestamp":1381165472000},"page":"497-503","source":"Crossref","is-referenced-by-count":27,"title":["Activin A and Follistatin as Biomarkers for Ectopic Pregnancy and Missed Abortion"],"prefix":"10.1155","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-9514","authenticated-orcid":true,"given":"Alexandros","family":"Daponte","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Biopolis, Larissa, 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