{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:16Z","timestamp":1740171796381,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"crossref","award":["SA-2010\/00","UFI 11\/44"],"award-info":[{"award-number":["SA-2010\/00","UFI 11\/44"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"crossref","award":["SA-2010\/00","UFI 11\/44"],"award-info":[{"award-number":["SA-2010\/00","UFI 11\/44"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV\/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis\/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland.<jats:italic>Methods.<\/jats:italic>The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues.<jats:italic>Results.<\/jats:italic>The activity of DPPIV\/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH.<jats:italic>Conclusions.<\/jats:italic>These data suggest the involvement of DPPIV\/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis\/prognosis of thyroid neoplasms.<\/jats:p>","DOI":"10.1155\/2013\/970736","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T23:03:25Z","timestamp":1385593405000},"page":"825-832","source":"Crossref","is-referenced-by-count":9,"title":["Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia"],"prefix":"10.1155","volume":"35","author":[{"given":"Gorka","family":"Larrinaga","sequence":"first","affiliation":[{"name":"Department of Nursing I, University School of Nursing, University of the Basque Country, P.O. Box 699, 48080 Bilbao, Bizkaia, Spain"},{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain"},{"name":"BioCruces Research Institute, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain"},{"name":"BioCruces Research Institute, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peio","family":"Errarte","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain"},{"name":"BioCruces Research Institute, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maider","family":"Beitia","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain"},{"name":"BioCruces Research Institute, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain"},{"name":"BioCruces Research Institute, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itxaro","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Nursing I, University School of Nursing, University of the Basque Country, P.O. 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