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However, it has never been addressed whether the MHC II pathway plays an important role in the development of nonalcoholic fatty liver disease, the most common form of liver disease. We used a mouse model that has a complete knockdown of genes in the MHC II pathway (MHCII<jats:sup>\u0394\/\u0394<\/jats:sup>). Firstly we studied the effect of high-fat diet-induced hepatic inflammation in these mice. Secondly we studied the development of carbon-tetra-chloride- (CCl<jats:sub>4<\/jats:sub>-) induced hepatic cirrhosis. After the high-fat diet, both groups developed obesity and hepatic steatosis with a similar degree of hepatic inflammation, suggesting no impact of the knockdown of MHC II on high-fat diet-induced inflammation in mice. In the second study, we confirmed that the CCl<jats:sub>4<\/jats:sub>injection significantly upregulated the MHC II genes in wild-type mice. The CCl<jats:sub>4<\/jats:sub>treatment significantly induced genes related to the fibrosis formation in wild-type mice, whereas this was lower in MHCII<jats:sup>\u0394\/\u0394<\/jats:sup>mice. The liver histology, however, showed no detectable difference between groups, suggesting that the MHC II pathway is not required for the development of hepatic fibrosis induced by CCl<jats:sub>4<\/jats:sub>.<\/jats:p>","DOI":"10.1155\/2013\/972962","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T21:01:55Z","timestamp":1366837315000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice"],"prefix":"10.1155","volume":"2013","author":[{"given":"Gilles","family":"Willemin","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Roger","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, 1010 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