{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:43:47Z","timestamp":1760204627101,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005849","name":"Baqiyatallah University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Previous studies have shown that morphine abuse during pregnancy cancause a delay in the development of the placenta and embryo and also bring about birth defects. The present study investigates the effect of the duration of maternal morphine consumption during pregnancy, as well as the impacts of morphine abuse on the development of placental layers during the three different periods of pregnancy in Wistar rats.<jats:italic>Materials and Methodology<\/jats:italic>. Female Wistar rats have been used in the present study. Experimental groups received morphine (0.05\u2009mg\/mL of drinking water) after one night of coupling with male rats for mating. On 9th, 10th, and 14th days of pregnancy, pregnant animals were killed, and placentas were removed and fixed. The cells of the placentas layers were calculated by light microscope and MOTIC and SPSS software.<jats:italic>Results<\/jats:italic>. The maternal surface thickness of the placenta was significantly increased, whereasthe fetal surface thickness of placenta was significantly decreased with morphine consumption with a time-dependent manner in experimental groups, compared to control groups. Moreover, the number of trophoblast cells increased in both maternal and fetal surfaces of placenta with respect to the duration of morphine consumption which was overt in the experimental groups compared to the control groups.<jats:italic>Conclusion<\/jats:italic>. In general, the time-dependent effects of oral morphine consumption can inhibit the development and natural functioning of cytotrophoblast and syncytiotrophoblast cells of the placental layers.<\/jats:p>","DOI":"10.1155\/2013\/974205","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T08:43:51Z","timestamp":1362386631000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Time-Dependent Effect of Oral Morphine Consumption on the Development of Cytotrophoblast and Syncytiotrophoblast Cells of the Placental Layers during the Three Different Periods of Pregnancy in Wistar Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Leila","family":"Dehghani","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedayat","family":"Sahraei","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran 1956837173, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rokhsareh","family":"Meamar","sequence":"additional","affiliation":[{"name":"Isfahan Neurosciences Research Center, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoomeh","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran 1956837173, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"3","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.3.6.819"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2134(96)00014-2"},{"issue":"1-2","key":"14","first-page":"369","volume":"2","year":"1975","journal-title":"Addictive Diseases"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500123996"},{"issue":"1","key":"2","first-page":"3","volume":"53","year":"1977","journal-title":"Advances in Anatomy, Embryology, and Cell Biology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01663.x"},{"issue":"5","key":"9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/rep.1.00033","volume":"127","year":"2004","journal-title":"Reproduction"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2005.06.012"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.09.052"},{"issue":"4","key":"10","first-page":"489","volume":"12","year":"2011","journal-title":"Cell Journal"},{"issue":"2","key":"11","first-page":"71","volume":"9","year":"2011","journal-title":"Iranian Journal of Reproductive Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.104141"},{"issue":"1310","key":"16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1098\/rspb.1991.0061","volume":"244","year":"1991","journal-title":"Proceedings of the Royal Society B"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod49.1.38","volume":"49","year":"1993","journal-title":"Biology of Reproduction"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/019262302753559614"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90001-5"},{"key":"5","first-page":"33","volume":"55","year":"2000","journal-title":"Progress in Drug Research"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06412.x"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/974205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/974205.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2013\/974205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T04:39:31Z","timestamp":1498019971000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2013\/974205\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"alternative-id":["974205","974205"],"URL":"https:\/\/doi.org\/10.1155\/2013\/974205","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"type":"print","value":"1740-2522"},{"type":"electronic","value":"1740-2530"}],"subject":[],"published":{"date-parts":[[2013]]}}}