{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:58:26Z","timestamp":1774443506434,"version":"3.50.1"},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The present study was undertaken to elucidate the effect of<jats:italic>Perilla frutescens<\/jats:italic>fixed oil on experimental esophagitis in albino rats. A group of rats (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:math>), treated with control vehicle (0.9% NaCl in double distilled water, 3\u2009mL\/kg, i.p.) and<jats:italic>Perilla frutescens<\/jats:italic>fixed oil (100%) (1, 2, and 3\u2009mL\/kg, i.p.), or pantoprazole (30\u2009mg\/kg, i.p.), were subjected to pylorus and forestomach ligation. Animals were sacrificed after 6\u2009h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with fixed oil significantly inhibited the gastric secretion, total acidity, and esophagitis index. The oil also helped to restore the altered levels of oxidative stress parameters to normal. The present study also makes evident the<jats:italic>in vitro<\/jats:italic>antihistaminic and anticholinergic activity of alpha linolenic acid (ALA) (18\u2009:\u20093,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>\u2212<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:math>) on isolated rat ileum preparation. The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic), and antioxidant activity of the oil was attributed for its efficacy in reflux esophagitis.<\/jats:p>","DOI":"10.1155\/2013\/981372","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T01:32:45Z","timestamp":1377048765000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["Effect of<i>Perilla frutescens<\/i>Fixed Oil on Experimental Esophagitis in Albino Wistar Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ekta","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (Central University), Vidya Vihar, Rai Bareli Road, Lucknow 226025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipta","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University 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