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Adult rats were treated with MeHg [5 mg\/kg\/day, intragastrically (i.g.)] and\/ or (PhSe)\n                    <jats:sub>2<\/jats:sub>\n                    [1 mg\/kg\/day, intraperitoneally (i.p.)] for 21 days. Body weight gain and motor deficits were evaluated prior to treatment, on treatment days 11 and 21. In addition, hepatic and cerebral mitochondrial function (reactive oxygen species (ROS) formation, total and nonprotein thiol levels, membrane potential (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi mathvariant=\"normal\">\u0394<\/mml:mi>\n                        <mml:mi mathvariant=\"normal\">\u03a8<\/mml:mi>\n                        <mml:mtext>m<\/mml:mtext>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), metabolic function, and swelling), hepatic, cerebral, and muscular mercury levels, and hepatic, cerebral, and renal thioredoxin reductase (TrxR) activity were evaluated. MeHg caused hepatic and cerebral mitochondrial dysfunction and inhibited TrxR activity in liver (38,9%), brain (64,3%), and kidney (73,8%). Cotreatment with (PhSe)\n                    <jats:sub>2<\/jats:sub>\n                    protected hepatic and cerebral mitochondrial thiols from depletion by MeHg but failed to completely reverse MeHg\u2019s effect on hepatic and cerebral mitochondrial dysfunction or hepatic, cerebral, and renal inhibition of TrxR activity. Additionally, the cotreatment with (PhSe)\n                    <jats:sub>2<\/jats:sub>\n                    increased Hg accumulation in the liver (50,5%) and brain (49,4%) and increased the MeHg-induced motor deficits and body-weight loss. In conclusion, these results indicate that (PhSe)\n                    <jats:sub>2<\/jats:sub>\n                    can increase Hg body burden as well as the neurotoxic effects induced by MeHg exposure in rats.\n                  <\/jats:p>","DOI":"10.1155\/2013\/983821","type":"journal-article","created":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T16:33:36Z","timestamp":1388334816000},"page":"1-12","source":"Crossref","is-referenced-by-count":26,"title":["Effects of Diphenyl Diselenide on Methylmercury Toxicity in Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Cristiane L.","family":"Dalla Corte","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology Department, Graduation Program in Biological Sciences: Toxicological Biochemistry, Natural and Exact Sciences Center, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Wagner","sequence":"additional","affiliation":[{"name":"Federal University of Pampa\u2014Ca\u00e7apava do Sul Campus, Avenida Pedro Anuncia\u00e7\u00e3o, Vila Batista, 96570-000 Ca\u00e7apava do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssie H.","family":"Sudati","sequence":"additional","affiliation":[{"name":"Federal University of Pampa\u2014Ca\u00e7apava do Sul Campus, Avenida Pedro Anuncia\u00e7\u00e3o, Vila Batista, 96570-000 Ca\u00e7apava do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Comparsi","sequence":"additional","affiliation":[{"name":"Higher Education Cenecista Institute of Santo \u00c2ngelo\u2014IESA, Rua Dr. Jo\u00e3o Augusto Rodrigues 471, 98801-015 Santo \u00c2ngelo, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlania O.","family":"Leite","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, Pharmacology and Molecular Chemistry Laboratory, Rua Cel. 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