{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:53:06Z","timestamp":1777002786170,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004876","name":"Sheffield Hospitals Charitable Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004876","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sleep Apnoea Trust Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1\u2009:\u20091 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (\u22121.8 [\u22123.0, \u22120.5]\u2009kg;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) and body fat percentage (\u22121 [\u22122, 0]%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>) and moderate improvements in C-reactive protein (\u22121.3 [\u22122.4, \u22120.2]\u2009mg\u00b7L<jats:sup>\u22121<\/jats:sup>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><\/mml:math>) and exercise capacity (95 [50, 139]\u2009m;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). At follow-up, changes in body mass (\u22122.0 [\u22123.5, \u22120.5]\u2009kg;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.010<\/mml:mn><\/mml:math>), body fat percentage (\u22121 [\u22122, 0]%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.033<\/mml:mn><\/mml:math>), and C-reactive protein (\u22121.3 [\u22122.5, \u22120.1]\u2009mg\u00b7L<jats:sup>\u22121<\/jats:sup>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.037<\/mml:mn><\/mml:math>) were maintained and exercise capacity was further improved (132 [90, 175]\u2009m;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). This trial is registered with ClinicalTrials.gov<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/results?term=NCT01546792&amp;Search=Search\">NCT01546792<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2014\/102164","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T21:01:32Z","timestamp":1405976492000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-1982","authenticated-orcid":true,"given":"James","family":"Moss","sequence":"first","affiliation":[{"name":"The Farr Institute of Health Informatics, Department of Epidemiology and Public Health, University College London, 222 Euston Road, London NW1 2DA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry Alan","family":"Tew","sequence":"additional","affiliation":[{"name":"York Trials Unit, University of York, Heslington, York YO10 5DD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert James","family":"Copeland","sequence":"additional","affiliation":[{"name":"Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield S10 2BP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stout","sequence":"additional","affiliation":[{"name":"North West Heart Centre, Wythenshawe Hospital, University Hospital of South Manchester, Southmoor Road, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Grant","family":"Billings","sequence":"additional","affiliation":[{"name":"Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield S5 7AU, 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