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The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>and increased expression of interleukin-1<jats:italic>\u03b2<\/jats:italic>, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-<jats:italic>\u03ba<\/jats:italic>B. The oral administration of DEC (50\u2009mg\/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. 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