{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:05:42Z","timestamp":1771463142806,"version":"3.50.1"},"reference-count":100,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6<jats:italic>de novo<\/jats:italic>synthesis present in<jats:italic>Plasmodium<\/jats:italic>, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).<\/jats:p>","DOI":"10.1155\/2014\/108516","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T21:03:01Z","timestamp":1389301381000},"page":"1-11","source":"Crossref","is-referenced-by-count":25,"title":["Vitamin B6-Dependent Enzymes in the Human Malaria Parasite<i>Plasmodium falciparum<\/i>: A Druggable Target?"],"prefix":"10.1155","volume":"2014","author":[{"given":"Thales","family":"Kronenberger","sequence":"first","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Lindner","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila A.","family":"Meissner","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via M.","family":"Zimbres","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika A.","family":"Coronado","sequence":"additional","affiliation":[{"name":"Multi User Center for Biomolecular Innovation, Department of Physics, S\u00e3o Paulo State University, UNESP\/IBILCE, C. Postal 136, 15054-000 S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isolmar","family":"Schettert","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), Avenida Doctor Eneas de Carvalho Aguiar 44, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Wrenger","sequence":"additional","affiliation":[{"name":"Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"3","key":"2","first-page":"299","volume":"14","year":"2010","journal-title":"Brazilian Journal of Infectious Diseases"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33996"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-122"},{"key":"5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tmaid.2013.01.006","volume":"11","year":"2013","journal-title":"Travel Medicine and Infectious Disease"},{"key":"6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm.3083","volume":"19","year":"2013","journal-title":"Nature Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.43"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.04.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.189"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040309"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00115-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.136"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.10.006"},{"key":"14","year":"1988"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor914"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070765"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1128\/jb.174.5.1554-1567.1992","volume":"174","year":"1992","journal-title":"Journal of Bacteriology"},{"issue":"9","key":"18","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/jb.171.9.4767-4777.1989","volume":"171","year":"1989","journal-title":"Journal of Bacteriology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2006.12.005"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412475200"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508696200"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9374"},{"issue":"4","key":"23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1097-2765(00)80060-X","volume":"1","year":"1998","journal-title":"Molecular Cell"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604950103"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503642200"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001815"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120925"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111542"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.09.011"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04257.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.10.010"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004406"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780597899"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.06.010"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.06.011"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20020834"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.11.018"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00357-7"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10274"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030614"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3520287"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0405-x"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807085200"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2011.07.004"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510233103"},{"issue":"34","key":"100","doi-asserted-by":"crossref","first-page":"17933","DOI":"10.1016\/S0021-9258(19)81306-6","volume":"263","year":"1988","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"57","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/bj2220815","volume":"222","year":"1984","journal-title":"Biochemical Journal"},{"issue":"1","key":"58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0014-4894(88)90004-5","volume":"67","year":"1988","journal-title":"Experimental Parasitology"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1645\/GE-179R"},{"issue":"3","key":"66","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/AAC.32.3.303","volume":"32","year":"1988","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"102","year":"1979"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(03)00032-2"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(95)00025-P"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.02.003"},{"issue":"5","key":"36","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1021\/bi00457a001","volume":"29","year":"1990","journal-title":"Biochemistry"},{"issue":"3","key":"37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0022-2836(84)90333-4","volume":"174","year":"1984","journal-title":"Journal of Molecular Biology"},{"key":"38","first-page":"129","volume":"74","year":"2000","journal-title":"Advances in Enzymology and Related Areas of Molecular Biology"},{"issue":"6","key":"39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/tcr.10005","volume":"1","year":"2001","journal-title":"Chemical Records"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.07.018"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305884200"},{"issue":"20","key":"43","first-page":"10438","volume":"29","year":"1998","journal-title":"Biochemistry"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-115121"},{"key":"45","first-page":"749","volume":"53","year":"1983","journal-title":"Annual Review of Biochemistry"},{"issue":"1","key":"46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/MMBR.49.1.81-99.1985","volume":"49","year":"1985","journal-title":"Microbiological Reviews"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031327"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.8097"},{"issue":"6","key":"49","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1096\/fasebj.4.6.2180768","volume":"4","year":"1990","journal-title":"FASEB Journal"},{"issue":"23","key":"50","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.84.23.8360","volume":"84","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.7149"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02078.x"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001021200"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.03.008"},{"issue":"1","key":"56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0005-2744(75)90022-4","volume":"403","year":"1975","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"59","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-4894(87)90148-2","volume":"64","year":"1987","journal-title":"Experimental Parasitology"},{"issue":"1","key":"60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-4894(85)80028-X","volume":"60","year":"1985","journal-title":"Experimental Parasitology"},{"issue":"2","key":"61","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1073\/pnas.86.2.651","volume":"86","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4467","key":"62","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.6775372","volume":"210","year":"1980","journal-title":"Science"},{"key":"63","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1007\/s00436-002-0766-5","volume":"90","year":"2003","journal-title":"Parasitology Research"},{"issue":"9174","key":"64","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0140-6736(05)66325-8","volume":"354","year":"1999","journal-title":"The Lancet"},{"issue":"6","key":"65","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1177\/030098588201900615","volume":"19","year":"1982","journal-title":"Veterinary Pathology"},{"key":"67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00685874","volume":"32","year":"1993","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"8","key":"68","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/jm00086a003","volume":"35","year":"1992","journal-title":"Journal of Medicinal Chemistry"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2857-2864.2005"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.173328"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.15.4421-4434.2001"},{"issue":"2","key":"73","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1432-1033.1993.tb17953.x","volume":"214","year":"1993","journal-title":"European Journal of Biochemistry"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309110003933"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1021\/bi700663n"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.2174\/138920012799320400"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl104"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.08.017"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03148.x"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1159\/000076737"},{"issue":"2","key":"82","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01117006","volume":"1","year":"1981","journal-title":"Bioscience Reports"},{"issue":"17","key":"83","doi-asserted-by":"crossref","first-page":"8235","DOI":"10.1016\/S0021-9258(18)47554-0","volume":"262","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00282-6"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07111.x"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2004.12.002"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1021\/bi00069a009"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.07.001"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.12003"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/108516.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/108516.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/108516.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T22:04:05Z","timestamp":1647986645000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/108516\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":100,"alternative-id":["108516","108516"],"URL":"https:\/\/doi.org\/10.1155\/2014\/108516","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}