{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:15:27Z","timestamp":1768454127997,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms were evaluated as possibly associated with end-stage renal disease (ESRD) resulting from type 2 diabetes mellitus (DM) nephropathy.<jats:italic>Methods<\/jats:italic>. Studies were conducted among hemodialysis (HD) patients with ESRD due to type 2 DM nephropathy, chronic glomerulonephritis, chronic infective tubulointerstitial nephritis, and hypertensive nephropathy as well as in healthy subjects. A frequency distribution of T-cell-related interleukin (IL) genes (<jats:italic>IL18<\/jats:italic>rs360719,<jats:italic>IL12A<\/jats:italic>rs568408,<jats:italic>IL12B<\/jats:italic>rs3212227,<jats:italic>IL4R<\/jats:italic>rs1805015,<jats:italic>IL13<\/jats:italic>rs20541,<jats:italic>IL28B<\/jats:italic>rs8099917,<jats:italic>IL28B<\/jats:italic>, and rs12979860) and vitamin D pathway genes (GC genes: rs2298849, rs7041, and rs1155563; VDR genes: rs2228570, rs1544410; and RXRA genes: rs10776909, rs10881578, and rs749759) was compared between groups.<jats:italic>Results<\/jats:italic>. No significant differences in a frequency distribution of tested polymorphisms were shown between type 2 DM nephropathy patients and controls. A difference was found in<jats:italic>IL18<\/jats:italic>rs360719 polymorphic distribution between the former group and chronic infective tubulointerstitial nephritic patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mi mathvariant=\"italic\">P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>trend<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.033<\/mml:mn><\/mml:math>), which also differed in this polymorphism from controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mi mathvariant=\"italic\">P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>trend<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. T-cell cytokine and vitamin D pathway gene polymorphisms are not associated with ESRD due to type 2 DM nephropathy in Polish HD patients.<jats:italic>IL18<\/jats:italic>rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis.<\/jats:p>","DOI":"10.1155\/2014\/120317","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T21:13:16Z","timestamp":1419282796000},"page":"1-17","source":"Crossref","is-referenced-by-count":9,"title":["T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Alicja E.","family":"Grzegorzewska","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Pozna\u0144 University of Medical Sciences (PUMS), 49 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