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Advanced age is the most important risk factor for neurological disease leading most often to poor prognosis in those afflicted. We report a case of WNV meningoencephalitis in a 93-year-old Caucasian male who presented with fever of unknown origin (FUO) and nuchal rigidity that rapidly decompensated within 24\u2009h to a persistent altered mental state during inpatient stay. The patient\u2019s ELISA antibody titers confirmed pathogenesis of disease by WNV; he given supportive measures and advanced to an excellent recovery. In regard to the approach of FUO, it is important to remain impartial yet insightful to all elements when determining pathogenesis in atypical presentation.<\/jats:p>","DOI":"10.1155\/2014\/120709","type":"journal-article","created":{"date-parts":[[2014,12,14]],"date-time":"2014-12-14T21:00:35Z","timestamp":1418590835000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Fever of Unknown Origin in a Patient with Confirmed West Nile Virus Meningoencephalitis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Alexander","family":"Sabre","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma de Guadalajara, Av Patria 1201, Lomas del Valle, 45129 Zapopan, JAl, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Farricielli","sequence":"additional","affiliation":[{"name":"Scottsdale Healthcare Shea Medical Center, 9003 E. 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