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The aim of the present study was to investigate how administration of the commonly used SSRI, fluoxetine, via a wafer cookie, compares to fluoxetine administration using an osmotic minipump, with regards to serum drug levels and hippocampal plasticity. For this experiment, adult female Sprague-Dawley rats were divided over the two administration methods: (1) cookie and (2) osmotic minipump and three fluoxetine treatment doses: 0, 5, or 10\u2009mg\/kg\/day. Results show that a fluoxetine dose of 5\u2009mg\/kg\/day, but not 10\u2009mg\/kg\/day, results in comparable serum levels of fluoxetine and its active metabolite norfluoxetine between the two administration methods. Furthermore, minipump administration of fluoxetine resulted in higher levels of cell proliferation in the granule cell layer (GCL) at a 5\u2009mg dose compared to a 10\u2009mg dose. Synaptophysin expression in the GCL, but not CA3, was significantly lower after fluoxetine treatment, regardless of administration method. These data suggest that the administration method and dose of fluoxetine can differentially affect hippocampal plasticity in the adult female rat.<\/jats:p>","DOI":"10.1155\/2014\/123026","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T17:01:02Z","timestamp":1395075662000},"page":"1-9","source":"Crossref","is-referenced-by-count":38,"title":["Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jodi L.","family":"Pawluski","sequence":"first","affiliation":[{"name":"GIGA-Neurosciences, University of Li\u00e8ge, 1 Avenue de l\u2019H\u00f4pital, B\u00e2timent B36, 4000 Li\u00e8ge, Belgium"},{"name":"School for Mental Health and Neuroscience, Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands"},{"name":"Department of Biological Sciences, Irvine Hall, Ohio University, Athens, OH 45701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"van Donkelaar","sequence":"additional","affiliation":[{"name":"School for Mental Health and Neuroscience, Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipporah","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Irvine Hall, Ohio University, Athens, OH 45701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-3768","authenticated-orcid":true,"given":"Virginie","family":"Houbart","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmacy, CIRM, University of Li\u00e8ge, 1 Avenue de l\u2019H\u00f4pital, B\u00e2timent B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9485","authenticated-orcid":true,"given":"Marianne","family":"Fillet","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmacy, CIRM, University of Li\u00e8ge, 1 Avenue de l\u2019H\u00f4pital, B\u00e2timent B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry W. 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