{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T10:02:55Z","timestamp":1648634575284},"reference-count":13,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chronic graft versus host disease (cGVHD) is a complication following bone marrow transplantation. The oral lesions are difficult to control with a systemic pharmacological therapy.<jats:italic>Case Description<\/jats:italic>. A 63-year-old female patient, who underwent an allogeniec transplantation for acute myeloid leukemia, developed a chronic oral and cutaneous GVHD. The patient was treated with topical tacrolimus 0.1%, twice daily for two months, and underwent a protocol of oral hygiene characterized by 3 appointments of scaling, root planning, and daily oral hygiene instructions. The patient showed marked resolution of gingival lesions and a significant improvement of related pain and gingival inflammatory indexes.<jats:italic>Clinical Implications<\/jats:italic>. This case report suggests that treatment with topical tacrolimus and professional oral hygiene may be helpful in the management of chronic oral GVHD with severe gingival involvement.<\/jats:p>","DOI":"10.1155\/2014\/127219","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T05:21:33Z","timestamp":1389244893000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Topical Tacrolimus and Periodontal Therapy in the Management of a Case of Oral Chronic GVHD Characterized by Specific Gingival Localization"],"prefix":"10.1155","volume":"2014","author":[{"given":"Davide","family":"Conrotto","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Carcieri","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Giaccone","sequence":"additional","affiliation":[{"name":"Division of Haematology, Azienda Ospedaliera Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo G.","family":"Arduino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01448.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01709.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2008.02.008"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.4.613"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.02.003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.301"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2011.00527.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080213"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000232287.08903.1d"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07679.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00666.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02272.x"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2014\/127219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2014\/127219.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crid\/2014\/127219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:58:51Z","timestamp":1471507131000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crid\/2014\/127219\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":13,"alternative-id":["127219","127219"],"URL":"https:\/\/doi.org\/10.1155\/2014\/127219","relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"value":"2090-6447","type":"print"},{"value":"2090-6455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}