{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:18:07Z","timestamp":1781705887746,"version":"3.54.5"},"reference-count":35,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Spanish Ministry of Health and Consumer Affairs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To estimate sensitivity and specificity of several optical coherence tomography (OCT) measurements for detecting retinal thickness changes in patients with relapsing-remitting multiple sclerosis (RRMS), such as macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with Cirrus (OCT) and peripapillary retinal nerve fiber layer (pRNFL) thickness measured with Cirrus and Spectralis OCT.<jats:italic>Methods<\/jats:italic>. Seventy patients (140 eyes) with RRMS and seventy matched healthy subjects underwent pRNFL and GCIPL thickness analysis using Cirrus OCT and pRNFL using Spectralis OCT. A prospective, cross-sectional evaluation of sensitivities and specificities was performed using latent class analysis due to the absence of a gold standard.<jats:italic>Results<\/jats:italic>. GCIPL measures had higher sensitivity and specificity than temporal pRNFL measures obtained with both OCT devices. Average GCIPL thickness was significantly more sensitive than temporal pRNFL by Cirrus (96.34% versus 58.41%) and minimum GCIPL thickness was significantly more sensitive than temporal pRNFL by Spectralis (96.41% versus 69.69%). Generalised estimating equation analysis revealed that age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.030<\/mml:mn><\/mml:math>), optic neuritis antecedent (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and disease duration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>) were significantly associated with abnormal results in average GCIPL thickness.<jats:italic>Conclusion<\/jats:italic>. Average and minimum GCIPL measurements had significantly better sensitivity to detect retinal thickness changes in RRMS than temporal pRNFL thickness measured by Cirrus and Spectralis OCT, respectively.<\/jats:p>","DOI":"10.1155\/2014\/128517","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T21:04:38Z","timestamp":1411074278000},"page":"1-10","source":"Crossref","is-referenced-by-count":61,"title":["Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Julio J.","family":"Gonz\u00e1lez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ram\u00f3n y Cajal University Hospital, Carretera de Colmenar Km 9, 1, 28034 Madrid, Spain"},{"name":"Department of Surgery, Alcal\u00e1 de Henares University, Madrid, Spain"},{"name":"Medical Retina Department, Moorfields Eye Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Rebolleda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ram\u00f3n y Cajal University Hospital, Carretera de Colmenar Km 9, 1, 28034 Madrid, Spain"},{"name":"Department of Surgery, Alcal\u00e1 de Henares University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Leal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ram\u00f3n y Cajal University Hospital, Carretera de Colmenar Km 9, 1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Oblanca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ram\u00f3n y Cajal University Hospital, Carretera de Colmenar Km 9, 1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Mu\u00f1oz-Negrete","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ram\u00f3n y Cajal University Hospital, Carretera de Colmenar Km 9, 1, 28034 Madrid, Spain"},{"name":"Department of Surgery, Alcal\u00e1 de Henares University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne","family":"Costa-Frossard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"\u00c1lvarez-Cerme\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ram\u00f3n y Cajal University Hospital, Madrid, 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