{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:03:36Z","timestamp":1763017416592,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To develop and test a risk-scoring model for the prediction of endometrial cancer among symptomatic postmenopausal women at risk of intrauterine malignancy.<jats:italic>Methods<\/jats:italic>. We prospectively studied 624 postmenopausal women with vaginal bleeding and endometrial thickness &gt; 4\u2009mm undergoing diagnostic hysteroscopy. Patient characteristics and endometrial assessment of women with or without endometrial cancer were compared. Then, a risk-scoring model, including the best predictors of endometrial cancer, was tested. Univariate, multivariate, and ROC curve analysis were performed. Finally, a split-sampling internal validation was also performed.<jats:italic>Results<\/jats:italic>. The best predictors of endometrial cancer were recurrent vaginal bleeding (odds ratio<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mtext>OR<\/mml:mtext><mml:mo stretchy=\"false\">)<\/mml:mo><mml:mo>=<\/mml:mo><mml:mn>2.96<\/mml:mn><\/mml:math>), the presence of hypertension<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.01<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>endometrial thickness &gt; 8\u2009mm<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.31<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>, and age &gt; 65 years<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.11<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. These variables were used to create a risk-scoring model (RHEA risk-model) for the prediction of intrauterine malignancy, with an area under the curve of 0.878 (95% CI 0.842 to 0.908;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). At the best cut-off value (score \u2265 4), sensitivity and specificity were 87.5% and 80.1%, respectively.<jats:italic>Conclusion<\/jats:italic>. Among symptomatic postmenopausal women with endometrial thickness &gt; 4\u2009mm, a risk-scoring model including patient characteristics and endometrial thickness showed a moderate diagnostic accuracy in discriminating women with or without endometrial cancer. Based on this model, a decision algorithm was developed for the management of such a population.<\/jats:p>","DOI":"10.1155\/2014\/130569","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T17:01:31Z","timestamp":1401814891000},"page":"1-7","source":"Crossref","is-referenced-by-count":30,"title":["A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness &gt; 4\u2009mm"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-8522","authenticated-orcid":true,"given":"Luca","family":"Giannella","sequence":"first","affiliation":[{"name":"Local Health Authority of Reggio Emilia, Division of Obstetrics and Gynecology, Cesare Magati Hospital, Viale Martiri della Libert\u00e0 6, Scandiano, 42019 Reggio Emilia, 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Local Health Authority of Reggio Emilia, Division of Obstetrics and Gynecology, Cesare Magati Hospital, Viale Martiri della Libert\u00e0 6, Scandiano, 42019 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Boselli","sequence":"additional","affiliation":[{"name":"Institute of Obstetrics and Gynecology, Oncology Prevention Unit, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"10","key":"1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.7863\/jum.2001.20.10.1025","volume":"20","year":"2001","journal-title":"Journal of Ultrasound in 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