{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:29:50Z","timestamp":1788870590692,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":98,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Guangdong Province Science Foundation","award":["S2011020005170"],"award-info":[{"award-number":["S2011020005170"]}]},{"name":"Guangdong Province Science Foundation","award":["20114425110011"],"award-info":[{"award-number":["20114425110011"]}]},{"name":"Doctoral Program of the Ministry of Education","award":["S2011020005170"],"award-info":[{"award-number":["S2011020005170"]}]},{"name":"Doctoral Program of the Ministry of Education","award":["20114425110011"],"award-info":[{"award-number":["20114425110011"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Zhen\u2010wu\u2010tang (ZWT), a well\u2010known formula in China, is widely used to treat chronic kidney diseases. However, very little information on ZWT\u2019s mechanism of action is currently available. In this study, we investigated the possible protective role and underlying mechanism of ZWT on nephrotic syndrome (NS) induced by Adriamycin (intravenous injection, 6.0\u2009mg\/kg) in rats using biochemical and histopathological approaches. ZWT decreased urine protein excretion and the serum levels of total cholesterol, triglycerides, blood urea nitrogen, and creatinine significantly in diseased rats. A decrease in plasma levels of total protein and albumin was also recorded in nephropathic rats. Pathological results show an improved pathological state and recovering glomerular structure in ZWT treatment groups. ZWT decreased renal IL\u20108 level but increased renal IL\u20104 level. In addition, rats subjected to ZWT exhibited less IgG deposition in glomerulus compared with model group. RT\u2010PCR results showed that ZWT decreased the mRNA expression of NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B p65 and increased the mRNA expression of I\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B. Furthermore, ZWT reduced the level of MDA and increased SOD activity. These results demonstrated that ZWT ameliorated Adriamycin\u2010induced NS in rats possibly by inhibiting Adriamycin\u2010induced inflammation damage, enhancing body\u2019s antioxidant capacity, thereby protecting glomerulus from injury.\n                  <\/jats:p>","DOI":"10.1155\/2014\/131604","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T17:21:04Z","timestamp":1397064064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Protection Effect of Zhen\u2010Wu\u2010Tang on Adriamycin\u2010Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage"],"prefix":"10.1155","volume":"2014","author":[{"given":"Chun-ling","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-biao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-mei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-fang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis Ya-xian","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-yao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"crossref","DOI":"10.1136\/adc.61.5.528","article-title":"Steroid responsive nephrotic syndrome in Asians","volume":"61","author":"Horvath M.","year":"1986","journal-title":"Archives of Disease in Childhood"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60439-0"},{"key":"e_1_2_9_3_2","volume-title":"Haerison\u2032s Nephrology and Acid-Base Disorders","author":"Lewis J. 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