{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:57:49Z","timestamp":1788587869918,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2006\/56319-1"],"award-info":[{"award-number":["2006\/56319-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The purpose of this study was to characterize the immunopathological response in the skin of<jats:italic>S. apella<\/jats:italic>infected with<jats:italic>Leishmania (L.) amazonensis<\/jats:italic>and<jats:italic>L. (V.) braziliensis<\/jats:italic>parasites, the main causative agents of localized cutaneous leishmaniasis in South America. In infected animals, amastigote forms of<jats:italic>L. (L.) amazonensis<\/jats:italic>could be detected till 120 days postinfection (PI), while, in<jats:italic>L. (V.) braziliensis<\/jats:italic>infection, parasites could be detected until 180 days PI in the skin sections. CD20<jats:sup>+<\/jats:sup>cells were detected throughout the experimental time in both groups as well as in CD3<jats:sup>+<\/jats:sup>cells, which appeared to be activated because high densities of inducible nitric oxide synthase (iNOS<jats:sup>+<\/jats:sup>) cells were detected at 60 and 90 days PI in both studied groups. After 60 and 120 days PI, decrease in iNOS<jats:sup>+<\/jats:sup>cells was observed in<jats:italic>L. (L.) amazonensis<\/jats:italic>and<jats:italic>L. (V.) braziliensis<\/jats:italic>, respectively, which was associated with parasite clearance. Increase in lysozyme<jats:sup>+<\/jats:sup>cells was observed during the experimental infections, which also can be associated with parasite killing.<\/jats:p>","DOI":"10.1155\/2014\/134236","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T17:01:05Z","timestamp":1409245265000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"title":["Dynamic of the Cellular Immune Response at the Dermal Site of<i>Leishmania (L.) amazonensis<\/i>and<i>Leishmania (V.) braziliensis<\/i>Infection in<i>Sapajus apella<\/i>Primate"],"prefix":"10.1155","volume":"2014","author":[{"given":"M\u00e1rcia Dalastra","family":"Laurenti","sequence":"first","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe Domingues","family":"Passero","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaise Yumie","family":"Tomokane","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Camargo","family":"Francesquini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mussya Cisotto","family":"Rocha","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Maria de Castro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo Pereira","family":"Corbett","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory (LIM-50), Pathology Department, Medical School of S\u00e3o Paulo University, Avenida Dr. Arnaldo, 455-1\u00b0 Andar, Sala 1209, 01246-903 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Tobias","family":"Silveira","sequence":"additional","affiliation":[{"name":"Leishmaniasis Laboratory, Evandro Chagas Institute, Ministry of Health, Rodovia BR 316 s\/n, 67030-000 Ananindeua, PA, Brazil"},{"name":"Tropical Medicine Nucleus, Par\u00e1 Federal University, Avenida General\u00edssimo Deodoro 92, 66055-240 Bel\u00e9m, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"S3","volume":"96","year":"2002","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/805108"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00190.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1614-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182012002156"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1126\/science.3287624"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821989000300003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821990000100002"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1590\/S0036-46651990000600001","volume":"32","year":"1990","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00078-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762004000300001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000100003"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4269\/ajtmh.1991.45.281","volume":"45","year":"1991","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2012.01370.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01116.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.05.002"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2006.02.005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.08.010"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034143"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116341"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4269\/ajtmh.1995.53.273","volume":"53","year":"1995","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.05.011"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.05.013"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386483-3.00003-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.5.12983"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/134236.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/134236.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/134236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:33:06Z","timestamp":1498145586000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/134236\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"alternative-id":["134236","134236"],"URL":"https:\/\/doi.org\/10.1155\/2014\/134236","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}