{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:12:33Z","timestamp":1767924753886,"version":"3.49.0"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>This study aimed to demonstrate if the addition of anti-inflammatory treatment to antibiotic therapy shows any superiority to the treatment with antibiotic only.<jats:italic>Methods.<\/jats:italic>Forty-nine Wistar rats were divided into 7 groups. Pyelonephritis was performed by<jats:italic>E. coli<\/jats:italic>injection to upper pole of kidneys except control group. Group 2 was not treated. Ceftriaxone, ketoprofen, \u201cceftriaxone + ketoprofen,\u201d methylprednisolone, and \u201cceftriaxone + methylprednisolone\u201d were given in the groups. The technetium-99m-dimercaptosuccinic acid scintigraphies were performed in 3rd day to detect pyelonephritis and 10th week to detect renal scarring. All kidneys were also histopathologically evaluated.<jats:italic>Results.<\/jats:italic>When 3rd day and 10th week scintigraphies were compared, initial 2.00 \u00b1 0.30 point pyelonephritis score resulted in 0.71 \u00b1 0.36 renal scar score in \u201cceftriaxone + ketoprofen\u201d group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.039<\/mml:mn><\/mml:math>). Initial 2.00 \u00b1 0.43 point pyelonephritis score resulted in 0.86 \u00b1 0.26 renal scar score in \u201cceftriaxone + methylprednisolone\u201d group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.041<\/mml:mn><\/mml:math>). Renal scar score was declined in \u201cceftriaxone + ketoprofen\u201d group and \u201cceftriaxone + methylprednisolone\u201d group compared with no-treatment group on 10th week of the study (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.026<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.044<\/mml:mn><\/mml:math>). On histopathological evaluation, it was seen that renal scar prevalence and expansion declined significantly in \u201cceftriaxone + ketoprofen and ceftriaxone + methylprednisolone\u201d (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.011<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.023<\/mml:mn><\/mml:math>).<jats:italic>Conclusion.<\/jats:italic>It was evidenced that ceftriaxone treatment in combination with ketoprofen or methylprednisolone declined scar formation in scintigraphic and histopathologic examinations of the kidneys.<\/jats:p>","DOI":"10.1155\/2014\/134940","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T21:01:59Z","timestamp":1404421319000},"page":"1-7","source":"Crossref","is-referenced-by-count":9,"title":["Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? 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