{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:33:43Z","timestamp":1784950423392,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A cross-sectional study was conducted to evaluate adverse effects associated with risperidone in 45 children with autism spectrum disorders (ASD), aged 2\u201315 years, who were treated at Siriraj Hospital, Thailand, between the years 2006 and 2007. Adverse effects were assessed by parent interview, using a semistructure questionnaire, and medical records review. The mean \u00b1 SD age of the children at starting risperidone was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">8.15<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.98<\/mml:mn><\/mml:math>years. The mean \u00b1 SD of risperidone dose was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">0.94<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.74<\/mml:mn><\/mml:math>\u2009mg\/day and the mean \u00b1 SD duration of treatment was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">36.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">27.8<\/mml:mn><\/mml:math>months. Adverse effects were reported in 39 children (86.7%). Common adverse effects included increased appetite, somnolence, and rhinorrhea and most of the adverse effects were tolerable. Tardive dyskinesia or other serious adverse events were not found in this study. The child\u2019s mean \u00b1 SD weight gain was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn fontstyle=\"italic\">4.18<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.82<\/mml:mn><\/mml:math>\u2009kg\/year, which exceeded developmentally expected norms. The results from this study suggest that risperidone treatment in children with ASD is associated with frequent mild and tolerable adverse effects. However, excessive weight gain could be found to be a concerning adverse effect and weight monitoring is warranted when risperidone is being prescribed.<\/jats:p>","DOI":"10.1155\/2014\/136158","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T16:01:02Z","timestamp":1391443262000},"page":"1-4","source":"Crossref","is-referenced-by-count":16,"title":["Adverse Effects of Risperidone in Children with Autism Spectrum Disorders in a Naturalistic Clinical Setting at Siriraj Hospital, Thailand"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6573-8044","authenticated-orcid":true,"given":"Vitharon","family":"Boon-yasidhi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantipa","family":"Jearnarongrit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patnaree","family":"Tulayapichitchock","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jariya","family":"Tarugsa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0021-9630.2003.00317.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2011.10.005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.4.587"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.10.011"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00004583-199804000-00014","volume":"37","year":"1998","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"6","key":"6","first-page":"559","volume":"46","year":"2001","journal-title":"Canadian Journal of Psychiatry"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/088307380101600602","volume":"16","year":"2001","journal-title":"Journal of Child Neurology"},{"key":"8","first-page":"S784","volume":"85","year":"2002","journal-title":"Journal of the Medical Association of Thailand"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013171"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0264-F"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2005.15.869"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1176\/appi.ajp.161.4.757","volume":"161","year":"2004","journal-title":"The American Journal of Psychiatry"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105056543"}],"container-title":["Psychiatry Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/136158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/136158.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/136158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T03:13:14Z","timestamp":1498101194000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/psychiatry\/2014\/136158\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":13,"alternative-id":["136158","136158"],"URL":"https:\/\/doi.org\/10.1155\/2014\/136158","relation":{},"ISSN":["2314-4327","2314-4335"],"issn-type":[{"value":"2314-4327","type":"print"},{"value":"2314-4335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}