{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:47:45Z","timestamp":1789771665282,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.<jats:italic>Methods<\/jats:italic>. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370\u2009nm, 3\u2009mW\/cm<jats:sup>2<\/jats:sup>, 30\u2009min).<jats:italic>Results<\/jats:italic>. The mean patient age was 14.3 \u00b1 2.4 years (range 8\u201317) and mean followup duration was 20.1 \u00b1 14.25 months (range 6\u201348). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06\u2009D in the steepest meridian. At 20 months after crosslinking, the values were 45.67\u2009D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:mrow><\/mml:math>) and 49.34\u2009D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:mrow><\/mml:math>), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.89<\/mml:mn><\/mml:mrow><\/mml:math>) and topometric astigmatism reduced from mean 3.50\u2009D to 3.25\u2009D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.51<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.<\/jats:p>","DOI":"10.1155\/2014\/140461","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T21:09:18Z","timestamp":1402520958000},"page":"1-5","source":"Crossref","is-referenced-by-count":29,"title":["Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2089-8164","authenticated-orcid":true,"given":"Deepa","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil L.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia"},{"name":"Sydney Adventist Hospital Clinical School, The University of Sydney, Sydney, NSW 2076, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Males","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia"},{"name":"Sydney Eye Hospital, The University of Sydney, Sydney, NSW 2000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1755-3768.1987.tb07038.x","volume":"65","year":"1987","journal-title":"Acta Ophthalmologica"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.05.029"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2005.12.092"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00407-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.039"},{"issue":"7","key":"8","doi-asserted-by":"crossref","first-page":"S720","DOI":"10.3928\/1081597X-20080901-15","volume":"24","year":"2008","journal-title":"Journal of Refractive Surgery"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.048"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.046"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.196493"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12035"},{"key":"14","first-page":"e26","volume":"2148","year":"2011","journal-title":"Journal of Pediatric Ophthalmology and Strabismus"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.03.020"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31822159f6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-02"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"issue":"2","key":"19","first-page":"94","volume":"211","year":"1997","journal-title":"Klinische Monatsblatter fur Augenheilkunde"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0410"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31826cf32d"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.017"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-01"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/140461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/140461.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/140461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T17:35:44Z","timestamp":1716831344000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/140461\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"alternative-id":["140461","140461"],"URL":"https:\/\/doi.org\/10.1155\/2014\/140461","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}