{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:32:54Z","timestamp":1778823174566,"version":"3.51.4"},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate diagnostic value of the virtual touch tissue quantification (VTTQ) for breast lesions with different sizes.<jats:italic>Materials and Methods<\/jats:italic>. Patients with 206 breast lesions were categorized into three groups according to lesion size (&lt;10\u2009mm, 10\u201320\u2009mm, and &gt;20\u2009mm). Breast lesions were examined by conventional ultrasound and VTTQ, and shear wave velocity (SWV) of each lesion and adjacent normal breast tissue were measured. Diagnoses were confirmed by pathological examination after surgery. The receiver-operating characteristic curve (ROC) analyses were performed to evaluate the diagnostic value of SWV, and the area under curves (AUC) was compared among groups.<jats:italic>Results<\/jats:italic>. SWV of malignant lesions was much higher than that of benign lesions, whereas the difference was not obvious for lesions &lt;10\u2009mm (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.15<\/mml:mn><\/mml:math>). There was statistical significant difference of AUC between lesions &lt;10\u2009mm and 10\u201320\u2009mm (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>), as well as lesions &lt;10\u2009mm and &gt;20\u2009mm (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>05<\/mml:mn><\/mml:math>). The sensitivity of lesions &lt;10\u2009mm was 33.33%, which was relatively low compared to other groups.<jats:italic>Conclusion<\/jats:italic>. According to our results, VTTQ is a promising method for breast lesions &gt;10\u2009mm, and further studies were warranted to improve sensitivity of VTTQ for breast lesions &lt;10\u2009mm.<\/jats:p>","DOI":"10.1155\/2014\/142504","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T23:04:49Z","timestamp":1396479889000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Diagnostic Value of Virtual Touch Tissue Quantification for Breast Lesions with Different Size"],"prefix":"10.1155","volume":"2014","author":[{"given":"Minghua","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Health Statistics, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, No. 301, Yanchangzhong Road, Zhabei, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"5","key":"1","first-page":"1531","volume":"31","year":"2012","journal-title":"Journal of Ultrasound in 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