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Northeast part of China has reported high prevalence of<jats:italic>H. pylori<\/jats:italic>infections and gastric cancer. Hence, we investigated the<jats:italic>H. pylori cagA<\/jats:italic>and<jats:italic>vacA<\/jats:italic>genotypes with clinical outcomes in Northeast China. Gastric tissue samples (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>169<\/mml:mn><\/mml:math>), chronic gastritis (GIs), gastric ulcer (GU), and gastric cancer (GC) were analysed for 16S rRNA<jats:italic>ureA<\/jats:italic>,<jats:italic>cagA<\/jats:italic>, and<jats:italic>cagA<\/jats:italic>genotypes by PCR. A total of 141 (84%) cases were found positive for<jats:italic>H. pylori<\/jats:italic>by 16S rRNA and<jats:italic>ureA<\/jats:italic>. GC showed high<jats:italic>H. pylori<\/jats:italic>infection (93%) compared with GIs (72%) and GU (84%). The<jats:italic>vacA<\/jats:italic>s1am1 was highly found in GC (40%) and GU (36%),<jats:italic>vacA<\/jats:italic>s1am2 in GIs (33%),<jats:italic>vacA<\/jats:italic>s1bm1 (14%) and<jats:italic>vacA<\/jats:italic>s1bm2 (8%) in GU cases, and s2m1 in normal cases (33%), while<jats:italic>vacA<\/jats:italic>s1cm1 showed low frequency in GIs (2%) and GU (3%) and GC showed negative result. The East-Asian<jats:italic>cagA<\/jats:italic>strain was highly observed in GC (43%), as compared to GIs (41%) and GU (20%). The East-Asian<jats:italic>cagA<\/jats:italic>\/<jats:italic>vacA<\/jats:italic>s1am1 was significantly higher in GC (23%) than in GU (22%) and GIs (145) patients. The East-Asian type<jats:italic>cagA<\/jats:italic>with<jats:italic>vacA<\/jats:italic>s1a and<jats:italic>vacA<\/jats:italic>m1 is the most predominant genotype in<jats:italic>H. pylori<\/jats:italic>strains of Northeast China.<\/jats:p>","DOI":"10.1155\/2014\/142980","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T21:12:52Z","timestamp":1400015572000},"page":"1-7","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence and Correlation with Clinical Diseases of<i>Helicobacter pylori cagA<\/i>and<i>vacA<\/i>Genotype among Gastric Patients from Northeast China"],"prefix":"10.1155","volume":"2014","author":[{"given":"Faisal","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, 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