{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T15:03:42Z","timestamp":1746803022462,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370450","CIT&TCD201304190"],"award-info":[{"award-number":["81370450","CIT&TCD201304190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Institutions","award":["81370450","CIT&TCD201304190"],"award-info":[{"award-number":["81370450","CIT&TCD201304190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogen<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-zearalanol treatment, the activity of cystathionine<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionine<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogen<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-zearalanol might be related to the reduction of cystathionine<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-synthase nitration.<\/jats:p>","DOI":"10.1155\/2014\/143192","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T03:10:12Z","timestamp":1395803412000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Alleviation of Plasma Homocysteine Level by Phytoestrogen<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>-Zearalanol Might Be Related to the Reduction of Cystathionine<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-Synthase Nitration"],"prefix":"10.1155","volume":"2014","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Luhe Hospital, Capital Medical University, 82 Xinhuanan Road, Tongzhou District, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingqiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Stomatological Hospital, Capital Medical University, 4 Tiantanxili, Dongcheng District, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Zuo","sequence":"additional","affiliation":[{"name":"Beijing Stomatological Hospital, Capital Medical University, 4 Tiantanxili, Dongcheng District, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huirong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-0773","authenticated-orcid":true,"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"},{"name":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"16","key":"1","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","year":"2002","journal-title":"The Journal of the American Medical Association"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.05.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.12.018"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01520.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.151"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.02.007"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:25:2:117"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/1961318a0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.05.005"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/813450"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2009.AMH006"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:25:2:121"},{"issue":"2","key":"13","first-page":"67","volume":"47","year":"2004","journal-title":"Chinese Journal of Physiology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.12.029"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2009.08.022"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0106-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.7.795"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0916-0"},{"issue":"2","key":"20","first-page":"191","volume":"58","year":"2007","journal-title":"Journal of Physiology and Pharmacology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2222"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/143192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/143192.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/143192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T06:21:39Z","timestamp":1498112499000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/143192\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":22,"alternative-id":["143192","143192"],"URL":"https:\/\/doi.org\/10.1155\/2014\/143192","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}