{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:37:29Z","timestamp":1768534649833,"version":"3.49.0"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100013213","name":"ARUP Institute for Clinical and Experimental Pathology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013213","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>To evaluate NOVA View with focus on reading archived images versus microscope based manual interpretation of ANA HEp-2 slides by an experienced, certified medical technologist.<jats:italic>Methods.<\/jats:italic>369 well defined sera from: 44 rheumatoid arthritis, 50 systemic lupus erythematosus, 35 scleroderma, 19 Sj\u00f6gren\u2019s syndrome, and 10 polymyositis patients as well as 99 healthy controls were examined. In addition, 12 defined sera from the Centers for Disease Control and 100 random patient sera sent to ARUP Laboratories for ANA HEp-2 IIF testing were included. Samples were read using the archived images on NOVA View and compared to results obtained from manual reading.<jats:italic>Results.<\/jats:italic>At a 1\u2009:\u200940\/1\u2009:\u200980 dilution the resulting comparison demonstrated 94.8%\/92.9% positive, 97.4%\/97.4% negative, and 96.5%\/96.2% total agreements between manual IIF and NOVA View archived images. Agreement of identifiable patterns between methods was 97%, with PCNA and mixed patterns undetermined.<jats:italic>Conclusion.<\/jats:italic>Excellent agreements were obtained between reading archived images on NOVA View and manually on a fluorescent microscope. In addition, workflow benefits were observed which need to be analyzed in future studies.<\/jats:p>","DOI":"10.1155\/2014\/149316","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T21:01:43Z","timestamp":1393275703000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Interpretation of ANA Indirect Immunofluorescence Test Outside the Darkroom Using NOVA View Compared to Manual Microscopy"],"prefix":"10.1155","volume":"2014","author":[{"given":"Susan S.","family":"Copple","sequence":"first","affiliation":[{"name":"ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT 84112, USA"},{"name":"Departments of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA"},{"name":"INOVA Diagnostics, Inc. 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