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RFA causes pneumothorax in up to 63% of cases, although pneumothorax requiring chest drainage occurs in less than 15% of procedures. Other severe complications are rare. After RFA of stage I NSCLC, 31\u201342% of patients show local progression. The 1-, 2-, 3-, and 5-year overall survival rates after RFA of stage I NSCLC were 78% to 100%, 53% to 86%, 36% to 88%, and 25% to 61%, respectively. The median survival time ranged from 29 to 67 months. The 1-, 2-, and 3-year cancer-specific survival rates after RFA of stage I NSCLC were 89% to 100%, 92% to 93%, and 59% to 88%, respectively. RFA has a higher local failure rate than sublobar resection and stereotactic body radiation therapy (SBRT). Therefore, RFA may currently be reserved for early-stage NSCLC patients who are unfit for sublobar resection or SBRT. Various technologies are being developed to improve clinical outcomes of RFA for early-stage NSCLC.<\/jats:p>","DOI":"10.1155\/2014\/152087","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T17:01:50Z","timestamp":1401814910000},"page":"1-11","source":"Crossref","is-referenced-by-count":45,"title":["Radiofrequency Ablation for Early-Stage Nonsmall Cell Lung Cancer"],"prefix":"10.1155","volume":"2014","author":[{"given":"Takao","family":"Hiraki","sequence":"first","affiliation":[{"name":"Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Gobara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, 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