{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:09:55Z","timestamp":1791173395670,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/05800-0"],"award-info":[{"award-number":["2011\/05800-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/17658-9"],"award-info":[{"award-number":["2013\/17658-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/05800-0"],"award-info":[{"award-number":["2011\/05800-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/17658-9"],"award-info":[{"award-number":["2013\/17658-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2011\/05800-0"],"award-info":[{"award-number":["2011\/05800-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2013\/17658-9"],"award-info":[{"award-number":["2013\/17658-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    Monensin A is a commercially important natural product isolated from\n                    <jats:italic>Streptomyces cinnamonensins<\/jats:italic>\n                    that is primarily employed to treat coccidiosis. Monensin A selectively complexes and transports sodium cations across lipid membranes and displays a variety of biological properties. In this study, we evaluated the Jacobsen catalyst as a cytochrome P450 biomimetic model to investigate the oxidation of monensin A. Mass spectrometry analysis of the products from these model systems revealed the formation of two products: 3-\n                    <jats:italic>O<\/jats:italic>\n                    -demethyl monensin A and 12-hydroxy monensin A, which are the same ones found in\n                    <jats:italic>in vivo<\/jats:italic>\n                    models. Monensin A and products obtained in biomimetic model were tested in a mitochondrial toxicity model assessment and an antimicrobial bioassay against\n                    <jats:italic>Staphylococcus aureus, S. aureus<\/jats:italic>\n                    methicillin-resistant,\n                    <jats:italic>Staphylococcus epidermidis, Pseudomonas aeruginosa,<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli.<\/jats:italic>\n                    Our results demonstrated the toxicological effects of monensin A in isolated rat liver mitochondria but not its products, showing that the metabolism of monensin A is a detoxification metabolism. In addition, the antimicrobial bioassay showed that monensin A and its products possessed activity against Gram-positive microorganisms but not for Gram-negative microorganisms. The results revealed the potential of application of this biomimetic chemical model in the synthesis of drug metabolites, providing metabolites for biological tests and other purposes.\n                  <\/jats:p>","DOI":"10.1155\/2014\/152102","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T17:03:44Z","timestamp":1401296624000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A"],"prefix":"10.1155","volume":"2014","author":[{"given":"Bruno Alves","family":"Rocha","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-901 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Rodrigo Moraes","family":"de 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Piacezzi Nascimento","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa, Desenvolvimento e Inova\u00e7\u00e3o, Apis Flora Industrial e Comercial LTDA, 140120-670 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andresa Aparecida","family":"Berretta","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa, Desenvolvimento e Inova\u00e7\u00e3o, Apis Flora Industrial e Comercial LTDA, 140120-670 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Ferranti","family":"Peti","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-901 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alberto Beraldo","family":"de 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