{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:27:03Z","timestamp":1791203223432,"version":"4.2.0"},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Research Fund of Strait (Xiamen) Technology Platform in Traditional Chinese Medicine","award":["3502Z20100006"],"award-info":[{"award-number":["3502Z20100006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Hyperlipidemia and many other metabolic diseases are related to oxidative stress.<jats:italic>Centella asiatica<\/jats:italic>is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of<jats:italic>Centella asiatica<\/jats:italic>had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of<jats:italic>Centella asiatica<\/jats:italic>has antioxidant and hypolipidemic properties.<\/jats:p>","DOI":"10.1155\/2014\/154295","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T21:03:55Z","timestamp":1397682235000},"page":"1-7","source":"Crossref","is-referenced-by-count":30,"title":["Effect of<i>Centella asiatica<\/i>on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yun","family":"Zhao","sequence":"first","affiliation":[{"name":"Medical College, Xiamen University, Xiang\u2019an District, Xiamen 361000, China"},{"name":"Xiamen Key Laboratory of Chiral Drugs, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Shu","sequence":"additional","affiliation":[{"name":"Medical College, Xiamen University, Xiang\u2019an District, Xiamen 361000, 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