{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:12:30Z","timestamp":1778926350619,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Dichloromethane and methanol extracts of seven different food and medicinal plants were tested in a screening platform for identification of extracts with potential bioactivity related to insulin\u2010dependent glucose uptake and fat accumulation. The screening platform included a series of <jats:italic>in vitro<\/jats:italic> bioassays, peroxisome proliferator\u2010activated receptor (PPAR) <jats:italic>\u03b3<\/jats:italic>\u2010mediated transactivation, adipocyte differentiation of 3T3\u2010L1 cell cultures, and glucose uptake in both 3T3\u2010L1 adipocytes and primary porcine myotubes, as well as one <jats:italic>in vivo<\/jats:italic> bioassay, fat accumulation in the nematode <jats:italic>Caenorhabditis elegans<\/jats:italic>. We found that dichloromethane extracts of aerial parts of golden root (<jats:italic>Rhodiola rosea<\/jats:italic>) and common elder (<jats:italic>Sambucus nigra<\/jats:italic>) as well as the dichloromethane extracts of thyme (<jats:italic>Thymus vulgaris<\/jats:italic>) and carrot (<jats:italic>Daucus carota<\/jats:italic>) were able to stimulate insulin\u2010dependent glucose uptake in both adipocytes and myotubes while weekly activating PPAR<jats:italic>\u03b3<\/jats:italic> without promoting adipocyte differentiation. In addition, these extracts were able to decrease fat accumulation in <jats:italic>C. elegans<\/jats:italic>. Methanol extracts of summer savory (<jats:italic>Satureja hortensis<\/jats:italic>), common elder, and broccoli (<jats:italic>Brassica oleracea<\/jats:italic>) enhanced glucose uptake in myotubes but were not able to activate PPAR<jats:italic>\u03b3<\/jats:italic>, indicating a PPAR<jats:italic>\u03b3<\/jats:italic>\u2010independent effect on glucose uptake.<\/jats:p>","DOI":"10.1155\/2014\/156398","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T21:01:05Z","timestamp":1409259665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation"],"prefix":"10.1155","volume":"2014","author":[{"given":"Rime B.","family":"El-Houri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Kotowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise C. 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