{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:38:46Z","timestamp":1770485926463,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,10,29]]},"abstract":"<jats:p><jats:italic>Malva parviflora<\/jats:italic>L. possesses significant antioxidant potential. This study was conducted to evaluate the neuroprotective effect of ethanol extract of the leaves of<jats:italic>Malva parviflora<\/jats:italic>against amyloid-<jats:italic>\u03b2<\/jats:italic>- (A<jats:italic>\u03b2<\/jats:italic>-) mediated Alzheimer\u2019s disease. In Morris water maze model, the extract significantly restored the defected memory of amyloid-<jats:italic>\u03b2<\/jats:italic>injected mice (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The reduced levels of brain antioxidant enzymes such as glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase were also restored significantly to similar levels as seen in normal control mice (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The levels of lipid peroxidase were decreased significantly in treatment group mice when compared to Alzheimer group mice (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). So, this study showed that ethanol extract of the leaves of<jats:italic>Malva parviflora<\/jats:italic>possesses neuroprotective activity in mice.<\/jats:p>","DOI":"10.1155\/2014\/156976","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T21:01:23Z","timestamp":1414616483000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["Neuroprotective Effect of Ethanol Extract of Leaves of<i>Malva parviflora<\/i>against Amyloid-<b><i>\u03b2<\/i>-<\/b>(A<b><i>\u03b2<\/i><\/b>-) Mediated Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-9658","authenticated-orcid":true,"given":"Muhammad","family":"Aslam","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Pharmacy, Ziauddin University, Karachi 75600, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Akbar","family":"Sial","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Ziauddin University, Karachi 75600, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199915050-00004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00115-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00035-5"},{"key":"4","year":"1962"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.09.032"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1039\/c2fo10153j"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4716"},{"key":"8","first-page":"326","volume":"5","year":"2006","journal-title":"Natural Product Radiance"},{"key":"9","first-page":"55","volume":"4","year":"2011","journal-title":"International Journal of Current Pharmaceutical Research"},{"issue":"3","key":"10","first-page":"234","volume":"5","year":"2012","journal-title":"Asian Journal of Pharmaceutical and Clinical Research"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/282698"},{"key":"12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","volume":"96","year":"1949","journal-title":"Journal of Pharmacology & Experimental Therapeutics"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v9i3.19105"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2922"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.1125"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/357368"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(81)90272-2"},{"key":"19","first-page":"674","volume-title":"Catalase","year":"1974"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722323.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00093-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199412000-00005"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.2174\/1567205053585945"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095857"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.09.014"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050161"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3767-09.2009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0136-3"}],"container-title":["International Scholarly Research Notices"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/156976.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/156976.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/156976.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T20:50:43Z","timestamp":1746478243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/156976\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,29]]},"references-count":30,"alternative-id":["156976","156976"],"URL":"https:\/\/doi.org\/10.1155\/2014\/156976","relation":{},"ISSN":["2356-7872"],"issn-type":[{"value":"2356-7872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,29]]}}}