{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:04:07Z","timestamp":1788879847319,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations.<jats:italic>Objectives<\/jats:italic>. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations.<jats:italic>Methods<\/jats:italic>. Data from the Swedish Medical Birth Register were used for the years 1996\u20132011 and infant malformations were identified from national health registers. Women with preexisting diabetes or reporting the use of thyreostatics, anticonvulsants, or antihypertensives were excluded from analysis. Risk estimates were made as odds ratios (ORs) or risk ratios (RRs) after adjustment for year of delivery, maternal age, parity, smoking, and body mass index.<jats:italic>Results<\/jats:italic>. Among 23\u2009259 infants whose mothers in early pregnancy used thyroxin, 730 had a major malformation; among all 1\u2009567\u2009736 infants, 48012 had such malformations. The adjusted OR was 1.06 (95% CI 0.98\u20131.14). For anal atresia the RR was 1.85 (95% CI 1.00\u20131.85) and for choanal atresia 3.14 (95% CI 1.26\u20136.47). The risk of some other malformations was also increased but statistical significance was not reached.<jats:italic>Conclusions<\/jats:italic>. Treated maternal hypothyroidism may be a weak risk factor for infant congenital malformations but an association with a few rare conditions is possible.<\/jats:p>","DOI":"10.1155\/2014\/160780","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T17:01:06Z","timestamp":1394643666000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["Maternal Hypothyroidism in Early Pregnancy and Infant Structural Congenital Malformations"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-8804","authenticated-orcid":true,"given":"Bengt","family":"K\u00e4ll\u00e9n","sequence":"first","affiliation":[{"name":"Tornblad Institute, Lund University, Biskopsgatan 7, 223 62 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Norstedt Wikner","sequence":"additional","affiliation":[{"name":"National Board of Health and Welfare, 10630 Stockholm, Sweden"},{"name":"Karolinska Institutet, Department of Medicine, Centre for Pharmacoepidemiology, 17176 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0002-9378(71)90825-8","volume":"109","year":"1971","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/426427"},{"key":"3","first-page":"123","volume":"153","year":"1958","journal-title":"Archiv f\u00fcr Kinderheilkunde"},{"key":"4","year":"1977"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1365-3016.1989.tb00528.x","volume":"3","year":"1989","journal-title":"Paediatric and Perinatal Epidemiology"},{"key":"6","first-page":"404","volume":"131","year":"2003","journal-title":"Revista M\u00e9dica de Chile"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802075103"},{"key":"8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/bdra.23091","volume":"94","year":"2012","journal-title":"Birth Defects Research A"}],"container-title":["Journal of Thyroid Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/160780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/160780.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/160780.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T05:30:43Z","timestamp":1498109443000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jtr\/2014\/160780\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":8,"alternative-id":["160780","160780"],"URL":"https:\/\/doi.org\/10.1155\/2014\/160780","relation":{},"ISSN":["2090-8067","2042-0072"],"issn-type":[{"value":"2090-8067","type":"print"},{"value":"2042-0072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}