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In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (<jats:bold>1b<\/jats:bold>), sulfaquinoxaline (<jats:bold>2b<\/jats:bold>), sulfadiazine (<jats:bold>3b<\/jats:bold>), sulfadimidine (<jats:bold>4b<\/jats:bold>), and sulfachloropyrazine (<jats:bold>5b<\/jats:bold>) (<jats:bold>1a<\/jats:bold>\u2013<jats:bold>5a<\/jats:bold>) were synthesized and characterized. Their carbonic anhydrase inhibition activity was evaluated against bovine cytosolic carbonic anhydrase isozyme II (bCA II). For the sake of comparison the CA inhibition activity of the parent sulfa drugs (<jats:bold>1b<\/jats:bold>\u2013<jats:bold>5b<\/jats:bold>) was also evaluated. A significant increase in CA inhibition activity of sulfa drugs was observed upon substitution with 2,4-dichloro-1,3,5-triazine moiety. Molecular docking studies were carried out to highlight binding site interactions. ADME properties were calculated to evaluate drug likeness of the compounds.<\/jats:p>","DOI":"10.1155\/2014\/162928","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T17:00:43Z","timestamp":1410195643000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mariya","family":"al-Rashida","sequence":"first","affiliation":[{"name":"Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, 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